Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000820.1:
Cluster 1Alkaloid18547

BGC0000820, physostigmine biosynthetic gene cluster from Streptomyces griseofuscus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: physostigmine
PubChem ID: 5983
SMILES string: Copy to clipboard
Molecular formula: C15H21N3O2
Average molecular mass: 275.352 Da
Molecular activity: Inhibitor

Class-specific details

Biosynthetic class(es):
Alkaloid subclass:

Gene cluster description

physostigmine (BGC0000820). Gene Cluster 1. Biosynthetic class = Alkaloid. GenBank KF201694. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Heterologous expression, Proven expression in natural host
Contact for this cluster:Joyce Liu (University of California, Berkeley)

Literature references

1. Liu J et al. (2014) Unusual acetylation-dependent reaction cascade in the biosynthesis of the pyrroloindole drug physostigmine. Angew Chem Int Ed Engl 53(1):136-9. doi: 10.1002/anie.201308069. Epub