BGC0000820: physostigmine biosynthetic gene cluster from Streptomyces griseofuscus
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Location: 1 - 8,547 nt. (total: 8,547 nt).
This entry is originally from NCBI GenBank KF201694.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000820
Short description physostigmine biosynthetic gene cluster from Streptomyces griseofuscus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
KF201694.1
via Knock-out studies, Enzymatic assays, Heterologous expression, Gene expression correlated with compound production
Compounds
  • physostigmine
Species Streptomyces griseofuscus [taxonomy]
References
Chemical products information
physostigmine Evidence:
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C15H21N3O2
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHL44339.1
  • psmA
 1 - 1008 (+) methyltransferase
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    • AHL44340.1
    • psmB
    		 1097 - 2026 (+) hydrolase
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      • AHL44341.1
      • psmC
      		 2060 - 2845 (+) methyltransferase
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        • AHL44342.1
        • psmD
        		 2861 - 3664 (+) methyltransferase
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          • AHL44343.1
          • psmE
          		 3668 - 5335 (+) carbamoyltransferase
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            • AHL44344.1
            • psmF
            		 5332 - 5880 (+) N-acetyltransferase
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              • AHL44345.1
              • psmG
              		 5864 - 7069 (+) putative tryptophan 2,3-dioxygenase
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                • AHL44346.1
                • psmH
                		 7066 - 8547 (+) PLP-dependent decarboxylase
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                  Biosynthesis information
                  Annotation changelog

                  Entry version: 4

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-10-07
                  Update chemical activity to schema version 2.11
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 3

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-09-15
                  Updated bioactivity data
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 2

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2019-10-16
                  Migrated from v1.4
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2019-10-16
                  Updated compound(s) information (NPAtlas curation)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 1

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2015-06-12
                  Submitted
                  • (ID: 4IL6M35C3LCTFERWKJH5IZTU)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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