BGC0000845: clavulanic acid biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
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Location: 177,438 - 210,968 nt. (total: 33,531 nt).
This entry is originally from NCBI GenBank DS570624.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000845
Short description clavulanic acid biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (non-nrp beta-lactam)
Loci
DS570624.1
177438 - 210968
via Enzymatic assays, Heterologous expression
Compounds
  • clavulanic acid
Species Streptomyces clavuligerus ATCC 27064 [taxonomy]
References
Chemical products information
clavulanic acid Evidence:
Copy SMILES
C8H9N1O5
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SSCG_00149
  • EDY47120.1
 177438 - 177650 (+) hypothetical protein
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    • SSCG_00150
    • EDY47122.1
    		 177939 - 179660 (+) carboxyethylarginine synthetase
    • Scaffold biosynthesis
    • Knock-out
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    • SSCG_00151
    • EDY47123.1
    		 179663 - 181204 (+) beta-lactam synthetase
    • Scaffold biosynthesis
    • Knock-out
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    • SSCG_00152
    • EDY47124.1
    		 181377 - 182318 (+) proclavaminate amidinohydrolase
    • Scaffold biosynthesis
    • Knock-out
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    • SSCG_00153
    • EDY47125.1
    		 182334 - 183311 (+) clavaminate synthase
    • Scaffold biosynthesis
    • Knock-out
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    • SSCG_00154
    • EDY47126.1
    		 183618 - 184799 (+) glutamate N-acetyltransferase 2
    • Precursor biosynthesis
    • Knock-out
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    • SSCG_00155
    • EDY47127.1
    		 184964 - 186631 (+) oligopeptide-binding lipoprotein
    • Transport
    • Knock-out
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    • SSCG_00156
    • EDY47128.1
    		 187415 - 188734 (-) transcription activator
    • Regulation
    • Knock-out
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    • SSCG_00157
    • EDY47129.1
    		 189039 - 189785 (-) clavaldehyde dehydrogenase
    • Scaffold biosynthesis
    • Knock-out
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    • SSCG_00158
    • EDY47130.1
    		 190186 - 191412 (+) cytochrome P450-SU2
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      • SSCG_00159
      • EDY47131.1
      		 191418 - 191624 (+) ferredoxin
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        • SSCG_00160
        • EDY47132.1
        		 191858 - 193234 (+) beta-lactamase
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          • SSCG_00161
          • EDY47133.1
          		 193231 - 194253 (+) efflux protein
          • Transport
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          • SSCG_00162
          • EDY47134.1
          		 194205 - 195224 (-) acetyltransferase
          • Scaffold biosynthesis
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          • SSCG_00163
          • EDY47135.1
          		 195611 - 196942 (-) oligopeptide-binding lipoprotein
          • Transport
          • Knock-out
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          • SSCG_00164
          • EDY47136.1
          		 197297 - 198502 (-) conserved hypothetical protein
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            • SSCG_00165
            • EDY47137.1
            		 198499 - 199887 (-) glycylclavaminate synthase
            • Scaffold biosynthesis
            • Knock-out
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            • SSCG_00166
            • EDY47138.1
            		 200085 - 201569 (-) penicillin-binding protein PBP
            • Resistance/immunity
            • Other in vivo study
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            • SSCG_00167
            • EDY47139.1
            		 202035 - 204329 (+) penicillin-binding protein
            • Resistance/immunity
            • Knock-out
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            • SSCG_00168
            • EDY47140.1
            		 204526 - 205707 (+) cytochrome P450 hydroxylase
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              • SSCG_00169
              • EDY47141.1
              		 206500 - 207105 (+) RNA polymerase sigma factor SigL
              • Regulation
              • Knock-out
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              • SSCG_00170
              • EDY47142.1
              		 207102 - 208652 (-) histidine kinase
              • Regulation
              • Knock-out
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              • SSCG_00171
              • EDY47143.1
              		 208814 - 209626 (-) two-component system response regulator
              • Regulation
              • Knock-out
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              • SSCG_00172
              • EDY47144.1
              		 210450 - 210968 (-) transcriptional regulator
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                Biosynthesis information
                Annotation changelog

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Removed gene names of 'No gene ID'
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Updated bioactivity data
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2015-06-12
                Submitted
                • (ID: SDHXYXULZ6ZTMHSITTYHRAHA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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