BGC0000872 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000872 (Streptomyces sp. SANK 60405)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T3PKS,nucleoside	1	35,385	High	A-90289 A/A-90289 B	other:other

BGC0000872 - Region 1 - T3PKS,nucleoside

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Location: 1 - 35,385 nt. (total: 35,385 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
nucleoside: (LipM or LipV or LipU or TunD or pur6 or pur10 or nikJ or nikO or truD)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 35,386
Label		BGC0000872

Tailoring functions

Oxidoreductases: dehydrogenase

lipV: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: aminotransferase glycosyltransferase methyltransferase sulfotransferase

lipB1: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

lipE: Sulfotransferase domain

extras: Sulfotransfer_4: Sulfotransferase domain

lipH: methyltransferase

smcogs: SMCOG1089: methyltransferase

lipJ: aminotransferase

smcogs: SMCOG1019: aminotransferase

lipO: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

lipW: methyltransferase

smcogs: SMCOG1089: methyltransferase

Ligases: synthase

lipC: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

lipD: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000872.5	1.63	other (other)	A-90289 A, A-90289 B	Streptomyces sp. SANK 60405
BGC0000875.4	0.96	other (nucleoside), saccharide	caprazamycin, caprazamycin aglycon	Streptomyces sp. MK730-62F2
BGC0001076.5	0.84	other (nucleoside)	liposidomycin B, liposidomycin A, liposidomycin C, liposidomycin Z, liposidomycin H, liposidomycin G, liposidomycin L, liposidomycin M, liposidomycin K, liposidomycin N	Streptomyces sp. SN-1061M
BGC0001905.4	0.41	PKS	violapyrone B	Streptomyces somaliensis
BGC0000860.3	0.31	other (other)	ectoine	Methylarcula marina
BGC0001927.4	0.30	other (other)	A-94964	Streptomyces sp.
BGC0001002.5	0.29	NRPS, PKS	jawsamycin	Streptomyces roseoverticillatus
BGC0000662.5	0.27	terpene	grixazone A	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001869.4	0.26	NRPS, other (phenazine)	griseoluteic acid, demethoxygriseoluteic acid, phenaszentine A, phenaszentine C, phenaszenketide C, phenaszenketide D	Xenorhabdus szentirmaii DSM 16338
BGC0001151.5	0.25	other (non-nrp beta-lactam)	valclavam, (-)-2-(2-hydroxyethyl)clavam	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000872.5	1.00	other (other)	A-90289 A, A-90289 B	Streptomyces sp. SANK 60405
BGC0000875.4	0.85	other (nucleoside), saccharide	caprazamycin, caprazamycin aglycon	Streptomyces sp. MK730-62F2
BGC0001076.5	0.79	other (nucleoside)	liposidomycin B, liposidomycin A, liposidomycin C, liposidomycin Z, liposidomycin H, liposidomycin G, liposidomycin L, liposidomycin M, liposidomycin K, liposidomycin N	Streptomyces sp. SN-1061M
BGC0001905.4	0.53	PKS	violapyrone B	Streptomyces somaliensis
BGC0001080.5	0.46	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0002573.2	0.46	other (other)	phosphoramidon	Streptomyces mozunensis
BGC0002561.3	0.46	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0001078.5	0.46	PKS, terpene	furaquinocin B	Streptomyces sp. KO-3988
BGC0000860.3	0.46	other (other)	ectoine	Methylarcula marina
BGC0001927.4	0.46	other (other)	A-94964	Streptomyces sp.

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

NRPS/PKS substrate predictions

lipQ: X

AMP-binding (89..304): X

nrpys: (unknown)

SVM prediction details:

NOTE: uncertain match

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ---LTG-FFK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor