BGC0000893: chloramphenicol biosynthetic gene cluster from Streptomyces venezuelae ATCC 10712
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Location: 1,039,846 - 1,061,851 nt. (total: 22,006 nt).
This entry is originally from NCBI GenBank FR845719.1.

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core biosynthetic genes
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Gene details
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General
Compounds
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NRP
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000893
Short description chloramphenicol biosynthetic gene cluster from Streptomyces venezuelae ATCC 10712
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "Chloramphenicol gene cluster comprises 17 genes (sven_0913 to sven_0929) including a monomodular NRPS. "
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: FR845719.1
Compounds
  • chloramphenicol
Species Streptomyces venezuelae ATCC 10712 [taxonomy]
References
Chemical products information
chloramphenicol
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C11H12Cl2N2O5
Chemical database entries
NPAtlas
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SVEN_0913
  • CCA54200.1
1039846 - 1040880 (+) CmlR
  • Regulation
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  • SVEN_0914
  • CCA54201.1
1040885 - 1041604 (-) CmlL
  • Scaffold biosynthesis
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  • SVEN_0915
  • CCA54202.1
1041601 - 1043019 (-) CmlN
  • Transport
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  • SVEN_0916
  • CCA54203.1
1043332 - 1044543 (+) CmlF
  • Transport
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  • SVEN_0917
  • CCA54204.1
1044647 - 1045909 (-) CmlE
  • Scaffold biosynthesis
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  • SVEN_0918
  • CCA54205.1
1045906 - 1046217 (-) CmlD
  • Scaffold biosynthesis
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  • SVEN_0919
  • CCA54206.1
1046214 - 1047200 (-) CmlC
  • Scaffold biosynthesis
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  • SVEN_0920
  • CCA54207.1
1047197 - 1049257 (-) CmlB
  • Scaffold biosynthesis
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  • SVEN_0921
  • CCA54208.1
1049401 - 1050999 (-) CmlA
  • Scaffold biosynthesis
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  • SVEN_0922
  • CCA54209.1
1051023 - 1053914 (-) CmlP
  • Scaffold biosynthesis
Sequence-based prediction
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  • SVEN_0923
  • CCA54210.1
1053898 - 1055076 (-) CmlH
  • Scaffold biosynthesis
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  • SVEN_0924
  • CCA54211.1
1055073 - 1056092 (-) CmlI
  • Scaffold biosynthesis
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  • SVEN_0925
  • CCA54212.1
1056366 - 1056692 (+) CmlM
  • Scaffold biosynthesis
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  • SVEN_0926
  • CCA54213.1
1056710 - 1057408 (+) CmlJ
  • Scaffold biosynthesis
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  • SVEN_0927
  • CCA54214.1
1057408 - 1058853 (+) CmlK
  • Scaffold biosynthesis
Sequence-based prediction
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  • SVEN_0928
  • CCA54215.1
1058957 - 1060672 (+) CmlS
  • Tailoring (Halogenation)
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  • SVEN_0929
  • CCA54216.1
1060871 - 1061851 (+) CmlT
  • Unknown
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NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Reductive release
Thioesterase genes
  • SVEN_0922 (Unknown)
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: RJXZFYIPTBJ27AV3IUUT4BRL, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed duplicate thioesterase
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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