BGC0000893: chloramphenicol biosynthetic gene cluster from Streptomyces venezuelae ATCC 10712
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1,039,846 - 1,061,851 nt. (total: 22,006 nt).
This entry is originally from NCBI GenBank FR845719.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000893
Short description chloramphenicol biosynthetic gene cluster from Streptomyces venezuelae ATCC 10712
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Chloramphenicol gene cluster comprises 17 genes (sven_0913 to sven_0929) including a monomodular NRPS. "
Biosynthetic class(es)
  • NRPS (Type I)
Loci
FR845719.1
1039846 - 1061851
via Knock-out studies, Enzymatic assays, Heterologous expression, Gene expression correlated with compound production
Compounds
  • chloramphenicol
Species Streptomyces venezuelae ATCC 10712 [taxonomy]
References
Chemical products information
chloramphenicol Evidence:
Copy SMILES
C11H12Cl2N2O5
Chemical database entries
NPAtlas
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SVEN_0913
  • CCA54200.1
 1039846 - 1040880 (+) CmlR
  • Regulation
  • Knock-out
copy AA seq
copy Nt seq
  • SVEN_0914
  • CCA54201.1
 1040885 - 1041604 (-) CmlL
  • Scaffold biosynthesis
  • Knock-out
copy AA seq
copy Nt seq
  • SVEN_0915
  • CCA54202.1
 1041601 - 1043019 (-) CmlN
  • Transport
  • Knock-out
copy AA seq
copy Nt seq
  • SVEN_0916
  • CCA54203.1
 1043332 - 1044543 (+) CmlF
  • Transport
copy AA seq
copy Nt seq
  • SVEN_0917
  • CCA54204.1
 1044647 - 1045909 (-) CmlE
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • SVEN_0918
  • CCA54205.1
 1045906 - 1046217 (-) CmlD
  • Scaffold biosynthesis
  • Other in vivo study
copy AA seq
copy Nt seq
  • SVEN_0919
  • CCA54206.1
 1046214 - 1047200 (-) CmlC
  • Scaffold biosynthesis
  • Other in vivo study
copy AA seq
copy Nt seq
  • SVEN_0920
  • CCA54207.1
 1047197 - 1049257 (-) CmlB
  • Scaffold biosynthesis
  • Other in vivo study
copy AA seq
copy Nt seq
  • SVEN_0921
  • CCA54208.1
 1049401 - 1050999 (-) CmlA
  • Scaffold biosynthesis
  • Activity assay
copy AA seq
copy Nt seq
  • SVEN_0922
  • CCA54209.1
 1051023 - 1053914 (-) CmlP
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • SVEN_0923
  • CCA54210.1
 1053898 - 1055076 (-) CmlH
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • SVEN_0924
  • CCA54211.1
 1055073 - 1056092 (-) CmlI
  • Scaffold biosynthesis
  • Activity assay
copy AA seq
copy Nt seq
  • SVEN_0925
  • CCA54212.1
 1056366 - 1056692 (+) CmlM
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • SVEN_0926
  • CCA54213.1
 1056710 - 1057408 (+) CmlJ
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • SVEN_0927
  • CCA54214.1
 1057408 - 1058853 (+) CmlK
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • SVEN_0928
  • CCA54215.1
 1058957 - 1060672 (+) CmlS
  • Tailoring
  • Activity assay
copy AA seq
copy Nt seq
  • SVEN_0929
  • CCA54216.1
 1060871 - 1061851 (+) CmlT
    copy AA seq
    copy Nt seq
    Biosynthesis information
    Annotation changelog

    Entry version: 4

    Date
    Changes
    Submitters
    Reviewers
    2022-10-07
    Update chemical activity to schema version 2.11
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 3

    Date
    Changes
    Submitters
    Reviewers
    2022-09-15
    Removed duplicate thioesterase
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2022-09-15
    Updated bioactivity data
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 2

    Date
    Changes
    Submitters
    Reviewers
    2019-10-16
    Migrated from v1.4
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2019-10-16
    Updated compound(s) information (MIBiG Annotathon)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2019-10-16
    Updated compound(s) information (NPAtlas curation)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 1

    Date
    Changes
    Submitters
    Reviewers
    2015-06-12
    Submitted
    • (ID: RJXZFYIPTBJ27AV3IUUT4BRL)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    Detailed domain annotation
    Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
    A domain glossary is available here, and an explanation of the visualisation is available here.
    Selected features only
    Show module domains
    Similar known gene clusters from MIBiG 4.0
    Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
    Click on reference genes to show details of similarities to genes within the current region.
    Click on an accession to open that entry in the MiBIG database.