BGC0000921: promysalin biosynthetic gene cluster from Pseudomonas putida
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Location: 4,335 - 20,085 nt. (total: 15,751 nt).
This entry is originally from NCBI GenBank GU211010.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000921
Short description promysalin biosynthetic gene cluster from Pseudomonas putida
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (shikimate-derived)
  • PKS (Unknown)
  • NRPS (Type I)
Loci
GU211010.1
4335 - 20085
via Knock-out studies, Heterologous expression
Compounds
  • promysalin
Species Pseudomonas putida [taxonomy]
References
Chemical products information
promysalin Evidence:
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C26H38N2O6
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADQ74607.1
  • ppgO
 4335 - 6323 (-) glutamine amidotransferase
  • Tailoring
  • Knock-out
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  • ADQ74608.1
  • ppgN
 6361 - 7359 (-) Rieske [2Fe-2S] domain protein
  • Tailoring
  • Knock-out
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  • ADQ74609.1
  • ppgA
 7778 - 8011 (+) carrier protein
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    • ADQ74610.1
    • ppgB
    		 8004 - 8771 (+) hypothetical protein
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      • ADQ74611.1
      • ppgC
      		 8791 - 9093 (+) acyl carrier protein
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        • ADQ74612.1
        • ppgD
        		 9090 - 9542 (+) beta-hydroxymyristoyl-acyl carrier protein dehydratase
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          • ADQ74613.1
          • ppgE
          		 9539 - 10525 (+) beta-ketoacyl synthase
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            • ADQ74614.1
            • ppgF
            		 10533 - 11525 (+) Rieske [2Fe-2S] domain protein
            • Scaffold biosynthesis
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            • ADQ74615.1
            • ppgG
            		 11592 - 11903 (+) isochorismate-pyruvate lyase
            • Scaffold biosynthesis
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            • ADQ74616.1
            • ppgH
            		 11900 - 13309 (+) isochorismate synthase
            • Scaffold biosynthesis
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            • ADQ74617.1
            • ppgI
            		 13347 - 14189 (+) metal-dependent hydrolase
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              • ADQ74618.1
              • ppgJ
              		 14216 - 15997 (+) amino acid adenylation protein
              • Scaffold biosynthesis
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              • ADQ74619.1
              • ppgK
              		 16011 - 17207 (+) beta-ketoacyl synthase
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                • ADQ74620.1
                • ppgL
                		 17204 - 18469 (+) BAHD family acyl transferase
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                  • ADQ74621.1
                  • ppgM
                  		 18466 - 20040 (+) salicylyl-AMP ligase
                  • Scaffold biosynthesis
                  • Knock-out
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                  Biosynthesis information

                  Biosynthetic modules

                  Name
                  1
                  Type
                  pks-trans-at
                  Genes
                  ppgK
                  Substrates
                  Integrated Monomers
                  Domains
                  ketosynthase
                  Name
                  0
                  Type
                  nrps-type1
                  Genes
                  ppgJ
                  Substrates
                  proline (evidence: Structure-based inference)
                  Integrated Monomers
                  Domains
                  adenylation
                  Annotation changelog

                  Entry version: 4

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-10-07
                  Update chemical activity to schema version 2.11
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 3

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-09-15
                  Corrected NRP module activity
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Changed amino acid substrates to lower case
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 2

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2019-10-16
                  Migrated from v1.4
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 1

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2015-06-12
                  Submitted
                  • (ID: KA3LORKD7MC3PYJEVNTA5TBS)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  Detailed domain annotation
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