BGC0000953: amicetin biosynthetic gene cluster from Streptomyces vinaceusdrappus
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Location: 1 - 37,337 nt. (total: 37,337 nt).
This entry is originally from NCBI GenBank HM748814.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000953
Short description amicetin biosynthetic gene cluster from Streptomyces vinaceusdrappus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • saccharide (aminoglycoside)
Loci
HM748814.1
via Knock-out studies, Enzymatic assays, Heterologous expression
Compounds
  • amicetin
Species Streptomyces vinaceusdrappus [taxonomy]
References
Chemical products information
amicetin Evidence:
Copy SMILES
C29H42N6O9
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEF16063.1
 1930 - 2970 (+) putative transcription antitermination regulator
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    • AEF16062.1
    		 4876 - 6066 (+) Mg or Mn-dependent protein phosphatase
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      • AEF16040.1
      • amiA
      		 7917 - 8711 (+) PabC
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        • AEF16041.1
        • amiB
        		 9160 - 10278 (+) NDP-sugar aminotransferase
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          • AEF16042.1
          • amic
          		 10275 - 11651 (+) NDP-hexose 2,3-dehydratase
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            • AEF16043.1
            • amiD
            		 11648 - 12616 (+) NDP-hexose 3-ketoreductase
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              • AEF16044.1
              • amiE
              		 12778 - 13551 (+) glucose-1-phosphate thymidylyltransferase
              • Precursor biosynthesis
              • Activity assay
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              • AEF16045.1
              • amiF
              		 13592 - 14998 (+) GCN5-like N-acetyltransferase
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                • AEF16046.1
                • amiG
                		 15035 - 16522 (+) glycosyltransferase
                • Tailoring
                • Knock-out Activity assay
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                • AEF16047.1
                • amiH
                		 16530 - 17279 (+) NDP-aminohexose N-dimethyltransferase
                • Tailoring
                • Knock-out
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                • AEF16048.1
                • amiI
                		 17276 - 17824 (+) deoxy cytidine deoxyribosyltransferase
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                  • AEF16049.1
                  • amiJ
                  		 17821 - 19032 (+) cytosylglucuronic acid synthase/glycosyltransferase
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                    • AEF16050.1
                    • amiK
                    		 19048 - 19995 (+) NDP-hexose 4-ketoreductase
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                      • AEF16051.1
                      • amiL
                      		 20038 - 21534 (+) benzoate-CoA synthase
                      • Precursor biosynthesis
                      • Knock-out
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                      • AEF16052.1
                      • amiM
                      		 21531 - 23564 (+) PABA synthase
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                        • AEF16053.1
                        • amiN
                        		 23609 - 24928 (+) CDP-4-keto-6-deoxyglucose-3-dehydratase
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                          • AEF16054.1
                          • amiO
                          		 24970 - 26649 (+) ABC transporter
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                            • AEF16055.1
                            • amiP
                            		 26996 - 27634 (+) TetR family transcriptional regulator
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                              • AEF16056.1
                              • amiQ
                              		 27684 - 28877 (+) major facilitator superfamily transporter
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                                • AEF16057.1
                                • amiR
                                		 28935 - 29834 (+) malonyl CoA-acyl carrier protein transacylase
                                • Tailoring
                                • Knock-out
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                                • AEF16058.1
                                • amiS
                                		 29925 - 31283 (+) glycine/serine hydroxymethyltransferase
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                                  • AEF16059.1
                                  • amiT
                                  		 31329 - 33794 (+) non-ribosomal peptide synthetase
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                                    • AEF16060.1
                                    • amiU
                                    		 33825 - 34889 (+) dTDP glucose 4,6-dehydratase
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                                      • AEF16061.1
                                      		 35653 - 36192 (-) GCN5-like N-acetyltransferase
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                                        Biosynthesis information
                                        Annotation changelog

                                        Entry version: 4

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2022-10-07
                                        Update chemical activity to schema version 2.11
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 3

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2022-09-15
                                        Updated bioactivity data
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 2

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2019-10-16
                                        Migrated from v1.4
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        2019-10-16
                                        Updated compound(s) information (NPAtlas curation)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 1

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2015-06-12
                                        Submitted
                                        • (ID: YU43TGF6RSKW2WJOQIFYBQO4)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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