BGC0000954: ajudazol A biosynthetic gene cluster from Chondromyces crocatus
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Location: 1 - 83,663 nt. (total: 83,663 nt).
This entry is originally from NCBI GenBank AM946600.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000954
Short description ajudazol A biosynthetic gene cluster from Chondromyces crocatus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: AM946600.1
Compounds
  • ajudazol A
Species Chondromyces crocatus [taxonomy]
References
Chemical products information
ajudazol A
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C34H42N2O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAQ18827.1
 6976 - 11652 (+) putative Trp
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  • CAQ18828.1
  • ajuA
 11896 - 18414 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAQ18829.1
  • ajuB
 18436 - 28647 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAQ18830.1
  • ajuC
 28650 - 35318 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAQ18831.1
  • ajuD
 35383 - 39609 (+) nonribosomal polypetide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAQ18832.1
  • ajuE
 39630 - 46166 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAQ18833.1
  • ajuF
 46163 - 50905 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAQ18834.1
  • ajuG
 50902 - 59742 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAQ18835.1
  • ajuH
 59739 - 64601 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAQ18836.1
  • ajuI
 64641 - 66017 (+) putative cytochrome P450
  • Tailoring (Oxidation)
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  • CAQ18837.1
  • ajuJ
 66033 - 67502 (-) putative cytochrome P450
  • Tailoring (Oxidation)
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  • CAQ18838.1
  • ajuK
 67689 - 73346 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAQ18839.1
  • ajuL
 73351 - 82734 (+) hybrid polyketide synthase/nonribosomal polypetide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
ajuC
+
ajuB
+
ajuA
+
ajuF
+
ajuE
+
ajuL
+
ajuH
+
ajuK
+
ajuG 		Synthase subclass: Modular type I
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ajuK
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 3
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ajuL
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ajuA
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 5
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ajuB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 6
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ajuB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 7
Specificity: Methylmalonyl-CoA
Genes: ajuC
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 9
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: ajuE
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 10
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ajuF
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 11
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ajuG
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 12
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ajuG
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 13
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ajuH
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Thiolation (ACP/PCP)
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
ajuD
Module 8
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
ajuL
Module 2
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: DCL
Modification domains: Methylation
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Sorted modules by module number
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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