BGC0000968: chaetoglobosin A biosynthetic gene cluster from Penicillium expansum
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Location: 1 - 25,930 nt. (total: 25,930 nt).
This entry is originally from NCBI GenBank AM779763.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000968
Short description chaetoglobosin A biosynthetic gene cluster from Penicillium expansum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
AM779763.1
via Gene expression correlated with compound production
Compounds
  • chaetoglobosin A
  • chaetoglobosin C
Species Penicillium expansum [taxonomy]
References
Chemical products information
chaetoglobosin A Evidence:
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C34H40N2O5
Chemical database entries
NPAtlas
chaetoglobosin C Evidence:
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C32H36N2O5
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAO91859.1
  • cheC
 1 - 2204 (+) putative transcription factor
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    • CAO91860.1
    • cheB
    		 2478 - 3661 (-) putative enoyl reductase
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      • CAO91861.1
      • cheA
      		 4198 - 16239 (+) PKS-NRPS hybrid
      • Scaffold biosynthesis
      • Other in vivo study
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      • CAO91862.1
      • cheD
      		 16833 - 18776 (-) putative monooxygenase
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        • CAO91863.1
        • cheE
        		 19231 - 21209 (+) putative monooxygenase
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          • CAO91864.1
          • cheF
          		 21322 - 23755 (-) putative transcription factor
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            • CAO91865.1
            • cheG
            		 24298 - 25930 (-) putative monooxygenase
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              Biosynthesis information

              Biosynthetic modules

              Name
              1
              Type
              nrps-type1
              Genes
              cheA
              Substrates
              tryptophan (evidence: Structure-based inference, Knock-out studies)
              Integrated Monomers
              Domains
              condensation, adenylation
              Annotation changelog

              Entry version: 4

              Date
              Changes
              Submitters
              Reviewers
              2022-10-07
              Update chemical activity to schema version 2.11
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 3

              Date
              Changes
              Submitters
              Reviewers
              2022-09-15
              Change compound name chaetoglobosins -> chaetoglobosin A (npatlas:NPA013078)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Added new compound: chaetoglobosin C (npatlas:NPA017501)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Corrected NRP module activity
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Corrected gene identifiers
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Updated NRP substrate specificities
              • (ID: H5KVDLSVQ3TJW7SKCDNBDEVC)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 2

              Date
              Changes
              Submitters
              Reviewers
              2019-10-16
              Migrated from v1.4
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              2015-06-12
              Submitted
              • (ID: ZUAEFEJPIFGA5SNZGJWBG3IU)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Detailed domain annotation
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