BGC0000973: collismycin A biosynthetic gene cluster from Streptomyces sp. CS40
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Location: 1 - 46,672 nt. (total: 46,672 nt).
This entry is originally from NCBI GenBank HE575208.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
Tailoring
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000973
Short description collismycin A biosynthetic gene cluster from Streptomyces sp. CS40
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
HE575208.1
via Knock-out studies
Compounds
  • collismycin A
Species Streptomyces sp. CS40 [taxonomy]
References
Chemical products information
collismycin A Evidence: NMR [1]
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C13H13N3O2S1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCC55901.1
 549 - 2237 (-) hypothetical protein
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    • CCC55902.1
    • clmR1
    		 2857 - 3414 (+) putative TetR transcriptional regulator
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      • CCC55903.1
      • clmT1
      		 3514 - 5247 (-) putative ABC transporter, ATPase and permease component
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        • CCC55904.1
        • clmT2
        		 5256 - 7016 (-) putative ABC transporter, ATPase and permease component
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          • CCC55905.1
          • clmT3
          		 7225 - 8193 (+) putative ABC transporter, solute binding protein
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            • CCC55906.1
            • clmT4
            		 8322 - 9305 (+) putative ABC transporter, permease component
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              • CCC55907.1
              • clmT5
              		 9314 - 10099 (+) putative ABC tarnsporter, ATP-binding protein
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                • CCC55908.1
                • clmR2
                		 10363 - 10869 (+) LuxR family transcriptional regulator
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                  • CCC55909.1
                  • clmM2
                  		 11042 - 12070 (-) O-methyltransferase
                  • Methylation
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                  • CCC55910.1
                  • clmD2
                  		 12105 - 13703 (-) putative dehydrogenase
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                    • CCC55911.1
                    • clmAT
                    		 13861 - 15495 (+) putative aminotransferase
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                      • CCC55912.1
                      • clmM1
                      		 15620 - 16606 (+) S-Methyltransferase
                      • Methylation
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                      • CCC55913.1
                      • clmG1
                      		 16688 - 18076 (-) GriD-like dehydrogenase component
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                        • CCC55914.1
                        • clmG2
                        		 18078 - 19109 (-) GriC-like dehydrogenase component
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                          • CCC55915.1
                          • clmM
                          		 19405 - 20613 (+) putative FAD dependent monooxygenase
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                            • CCC55916.1
                            • clmAH
                            		 20680 - 21921 (-) amidohydrolase
                            • Hydrolysis
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                            • CCC55917.1
                            • clmAL
                            		 21926 - 23614 (-) putative acyl CoA ligase
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                              • CCC55918.1
                              • clmP
                              		 23611 - 23871 (-) putative free-standing acyl carrier protein
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                                • CCC55919.1
                                • clmL
                                		 24108 - 25484 (+) L-Lysine 2-aminotransferase
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                                  • CCC55920.1
                                  • clmS
                                  		 25481 - 26662 (+) monomeric sarcosine oxidase
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                                    • CCC55921.1
                                    • clmN1
                                    		 26548 - 34206 (+) non-ribosomal peptide synthetase/polyketide synthase hybrid protein
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                                      • CCC55922.1
                                      • clmN2
                                      		 34203 - 37478 (+) putative non-ribosomal peptide synthetase
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                                        • CCC55923.1
                                        • clmD1
                                        		 37475 - 38659 (+) putative acyl-CoA dehydrogenase
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                                          • CCC55924.1
                                          • clmT
                                          		 38652 - 39380 (+) putative type II thioesterase
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                                            • CCC55925.1
                                            		 39442 - 40665 (-) hypothetical protein
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                                              • CCC55926.1
                                              		 41103 - 41708 (+) hypothetical protein
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                                                • CCC55927.1
                                                		 42017 - 46105 (+) hypothetical protein
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                                                  Biosynthesis information

                                                  Biosynthetic modules

                                                  Name
                                                  2
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  clmN1
                                                  Substrates
                                                  cysteine (evidence: Sequence-based prediction)
                                                  Integrated Monomers
                                                  Domains
                                                  condensation (Heterocyclization), adenylation, epimerase
                                                  Name
                                                  3
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  clmN2
                                                  Substrates
                                                  leucine (evidence: )
                                                  Integrated Monomers
                                                  Domains
                                                  condensation, adenylation
                                                  Name
                                                  0
                                                  Type
                                                  pks-trans-at-starter
                                                  Genes
                                                  clmP
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  carrier (ACP)
                                                  Name
                                                  1
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  clmN1
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                  Annotation changelog

                                                  Entry version: 5

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2024-05-30
                                                  MIBiG v4 annotathon
                                                  • (ID: P75FRHHCFPTCPYSP65VDVPHW)
                                                  • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 4

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-10-07
                                                  Update chemical activity to schema version 2.11
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 3

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-09-15
                                                  Linked new NPAtlas id for collismycin A (npatlas:NPA020595)
                                                  • (ID: H5KVDLSVQ3TJW7SKCDNBDEVC)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-09-15
                                                  Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-09-15
                                                  Updated bioactivity data
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-09-15
                                                  Updated NRP substrate specificities
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 2

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2019-10-16
                                                  Migrated from v1.4
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 1

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2015-06-12
                                                  Submitted
                                                  • (ID: IROSGRAECON7XFWB774QFHDN)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  Tailoring functions
                                                  Tailoring enzymes detected in this region
                                                  Oxidoreductases: dehydrogenase oxidase oxidoreductase oxygenase
                                                  CCC55925.1: cytochrome P450
                                                  smcogs
                                                  SMCOG1007: cytochrome P450
                                                  clmD1: acyl-CoA dehydrogenase
                                                  smcogs
                                                  SMCOG1006: acyl-CoA dehydrogenase
                                                  clmD2: FAD linked oxidase domain protein
                                                  smcogs
                                                  SMCOG1138: FAD linked oxidase domain protein
                                                  clmG1: aldehyde dehydrogenase
                                                  smcogs
                                                  SMCOG1017: aldehyde dehydrogenase
                                                  clmS: FAD dependent oxidoreductase
                                                  smcogs
                                                  SMCOG1103: FAD dependent oxidoreductase
                                                  Transferases: aminotransferase halogenase methyltransferase
                                                  clmAT: aminotransferase class-III
                                                  smcogs
                                                  SMCOG1013: aminotransferase class-III
                                                  clmL: DegT/DnrJ/EryC1/StrS aminotransferase
                                                  smcogs
                                                  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase
                                                  clmM: halogenase
                                                  smcogs
                                                  SMCOG1119: halogenase
                                                  clmM1: Methylation
                                                  MITE
                                                  MITE0000074Methylation (identity: 100.00%)
                                                  smcogs
                                                  SMCOG1042: O-methyltransferase
                                                  clmM2: Methylation
                                                  MITE
                                                  MITE0000075Methylation (identity: 100.00%)
                                                  smcogs
                                                  SMCOG1042: O-methyltransferase
                                                  Hydrolases: Hydrolysis esterase
                                                  clmAH: Hydrolysis
                                                  MITE
                                                  MITE0000073Hydrolysis (identity: 100.00%)
                                                  clmT: thioesterase
                                                  smcogs
                                                  SMCOG1004: thioesterase
                                                  Ligases: ligase synthase
                                                  CCC55927.1: AMP-dependent synthetase and ligase
                                                  smcogs
                                                  SMCOG1002: AMP-dependent synthetase and ligase
                                                  clmAL: AMP-dependent synthetase and ligase
                                                  smcogs
                                                  SMCOG1002: AMP-dependent synthetase and ligase
                                                  clmN1: Beta-ketoacyl synthase
                                                  smcogs
                                                  SMCOG1022: Beta-ketoacyl synthase
                                                  clmN2: condensation domain-containing protein
                                                  smcogs
                                                  SMCOG1127: condensation domain-containing protein
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                                                  Detailed domain annotation
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