BGC0000973: collismycin A biosynthetic gene cluster from Streptomyces sp. CS40
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Location: 1 - 46,672 nt. (total: 46,672 nt).
This entry is originally from NCBI GenBank HE575208.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000973
Short description collismycin A biosynthetic gene cluster from Streptomyces sp. CS40
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
HE575208.1
via Knock-out studies
Compounds
  • collismycin A
Species Streptomyces sp. CS40 [taxonomy]
References
Chemical products information
collismycin A Evidence: NMR [1]
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C13H13N3O2S1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCC55901.1
 549 - 2237 (-) hypothetical protein
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    • CCC55902.1
    • clmR1
    		 2857 - 3414 (+) putative TetR transcriptional regulator
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      • CCC55903.1
      • clmT1
      		 3514 - 5247 (-) putative ABC transporter, ATPase and permease component
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        • CCC55904.1
        • clmT2
        		 5256 - 7016 (-) putative ABC transporter, ATPase and permease component
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          • CCC55905.1
          • clmT3
          		 7225 - 8193 (+) putative ABC transporter, solute binding protein
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            • CCC55906.1
            • clmT4
            		 8322 - 9305 (+) putative ABC transporter, permease component
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              • CCC55907.1
              • clmT5
              		 9314 - 10099 (+) putative ABC tarnsporter, ATP-binding protein
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                • CCC55908.1
                • clmR2
                		 10363 - 10869 (+) LuxR family transcriptional regulator
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                  • CCC55909.1
                  • clmM2
                  		 11042 - 12070 (-) O-methyltransferase
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                    • CCC55910.1
                    • clmD2
                    		 12105 - 13703 (-) putative dehydrogenase
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                      • CCC55911.1
                      • clmAT
                      		 13861 - 15495 (+) putative aminotransferase
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                        • CCC55912.1
                        • clmM1
                        		 15620 - 16606 (+) S-Methyltransferase
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                          • CCC55913.1
                          • clmG1
                          		 16688 - 18076 (-) GriD-like dehydrogenase component
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                            • CCC55914.1
                            • clmG2
                            		 18078 - 19109 (-) GriC-like dehydrogenase component
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                              • CCC55915.1
                              • clmM
                              		 19405 - 20613 (+) putative FAD dependent monooxygenase
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                                • CCC55916.1
                                • clmAH
                                		 20680 - 21921 (-) amidohydrolase
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                                  • CCC55917.1
                                  • clmAL
                                  		 21926 - 23614 (-) putative acyl CoA ligase
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                                    • CCC55918.1
                                    • clmP
                                    		 23611 - 23871 (-) putative free-standing acyl carrier protein
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                                      • CCC55919.1
                                      • clmL
                                      		 24108 - 25484 (+) L-Lysine 2-aminotransferase
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                                        • CCC55920.1
                                        • clmS
                                        		 25481 - 26662 (+) monomeric sarcosine oxidase
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                                          • CCC55921.1
                                          • clmN1
                                          		 26548 - 34206 (+) non-ribosomal peptide synthetase/polyketide synthase hybrid protein
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                                            • CCC55922.1
                                            • clmN2
                                            		 34203 - 37478 (+) putative non-ribosomal peptide synthetase
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                                              • CCC55923.1
                                              • clmD1
                                              		 37475 - 38659 (+) putative acyl-CoA dehydrogenase
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                                                • CCC55924.1
                                                • clmT
                                                		 38652 - 39380 (+) putative type II thioesterase
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                                                  • CCC55925.1
                                                  		 39442 - 40665 (-) hypothetical protein
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                                                    • CCC55926.1
                                                    		 41103 - 41708 (+) hypothetical protein
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                                                      • CCC55927.1
                                                      		 42017 - 46105 (+) hypothetical protein
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                                                        Biosynthesis information

                                                        Biosynthetic modules

                                                        Name
                                                        2
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        clmN1
                                                        Substrates
                                                        cysteine (evidence: Sequence-based prediction)
                                                        Integrated Monomers
                                                        Domains
                                                        condensation (Heterocyclization), adenylation, epimerase
                                                        Name
                                                        3
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        clmN2
                                                        Substrates
                                                        leucine (evidence: )
                                                        Integrated Monomers
                                                        Domains
                                                        condensation, adenylation
                                                        Name
                                                        0
                                                        Type
                                                        pks-trans-at-starter
                                                        Genes
                                                        clmP
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        carrier (ACP)
                                                        Name
                                                        1
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        clmN1
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                        Annotation changelog

                                                        Entry version: next

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2024-05-30
                                                        MIBiG v4 annotathon
                                                        • (ID: P75FRHHCFPTCPYSP65VDVPHW)
                                                        • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 4

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-10-07
                                                        Update chemical activity to schema version 2.11
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 3

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-09-15
                                                        Linked new NPAtlas id for collismycin A (npatlas:NPA020595)
                                                        • (ID: H5KVDLSVQ3TJW7SKCDNBDEVC)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-09-15
                                                        Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-09-15
                                                        Updated bioactivity data
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-09-15
                                                        Updated NRP substrate specificities
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 2

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2019-10-16
                                                        Migrated from v1.4
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 1

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2015-06-12
                                                        Submitted
                                                        • (ID: IROSGRAECON7XFWB774QFHDN)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        Detailed domain annotation
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