BGC0000978: cylindrospermopsin biosynthetic gene cluster from Cylindrospermopsis raciborskii AWT205
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Location: 1 - 42,156 nt. (total: 42,156 nt).
This entry is originally from NCBI GenBank EU140798.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000978
Short description cylindrospermopsin biosynthetic gene cluster from Cylindrospermopsis raciborskii AWT205
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
  • other (other)
Loci
EU140798.1
via
Compounds
  • cylindrospermopsin
Species Cylindrospermopsis raciborskii AWT205 [taxonomy]
References
Chemical products information
cylindrospermopsin Evidence:
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C15H21N5O7S1
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABX60152.1
  • cyrD
 444 - 6074 (+) polyketide synthase
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    • ABX60153.1
    • cyrF
    		 6130 - 10203 (+) polyketide synthase
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      • ABX60154.1
      • cyrG
      		 10251 - 11687 (+) putative uracil ring formation
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        • ABX60155.1
        • cyrI
        		 11741 - 12571 (+) proline dioxygenase-like protein
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          • ABX60156.1
          • cyrK
          		 12568 - 13965 (-) multidrug exporter MatE
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            • ABX60157.1
            • cyrL
            		 14037 - 14786 (+) transposase
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              • ABX60158.1
              • cyrH
              		 14886 - 16316 (+) aminohydrolase
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                • ABX60159.1
                • cyrJ
                		 16893 - 17672 (+) putative sulfotransferase
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                  • ABX60160.1
                  • cyrA
                  		 18113 - 19288 (+) amidinotransferase
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                    • ABX60161.1
                    • cyrB
                    		 19303 - 28056 (+) mixed NRPS/PKS
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                      • ABX60162.1
                      • cyrE
                      		 28061 - 33727 (+) polyketide synthase
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                        • ABX60163.1
                        • cyrC
                        		 34299 - 39302 (+) polyketide synthase
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                          • ABX60164.1
                          • cyrN
                          		 39793 - 40392 (-) adenylylsulfate kinase
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                            • ABX60165.1
                            • cyrO
                            		 40501 - 42048 (+) CyrO
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              0
                              Type
                              nrps-type1
                              Genes
                              cyrB
                              Substrates
                              guanidinoacetic acid (evidence: Activity assay)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              1
                              Type
                              pks-modular
                              Genes
                              cyrD
                              Substrates
                              Integrated Monomers
                              Domains
                              acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                              Name
                              2
                              Type
                              pks-modular
                              Genes
                              cyrF
                              Substrates
                              Integrated Monomers
                              Domains
                              acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                              Name
                              3
                              Type
                              pks-modular
                              Genes
                              cyrB
                              Substrates
                              Integrated Monomers
                              Domains
                              acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, methyltransferase, carrier (ACP)
                              Name
                              4
                              Type
                              pks-modular
                              Genes
                              cyrE
                              Substrates
                              Integrated Monomers
                              Domains
                              acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                              Name
                              5
                              Type
                              pks-modular
                              Genes
                              cyrC
                              Substrates
                              Integrated Monomers
                              Domains
                              acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                              Annotation changelog

                              Entry version: 4

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Corrected NRP module activity
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Updated NRP substrate specificities
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2015-06-12
                              Submitted
                              • (ID: EI7LXM427LE4WIOQ5U54V3BB)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Detailed domain annotation
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