BGC0000998: guadinomine biosynthetic gene cluster from Streptomyces sp. K01-0509
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Location: 1 - 51,101 nt. (total: 51,101 nt).
This entry is originally from NCBI GenBank JX545234.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000998
Short description guadinomine biosynthetic gene cluster from Streptomyces sp. K01-0509
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
JX545234.1
via
Compounds
  • guadinomine
  • guadinomine B
  • guadinomic acid
Species Streptomyces sp. K01-0509 [taxonomy]
References
Chemical products information
guadinomine Evidence:
(no structure information available)
Chemical database entries
NPAtlas
guadinomine B Evidence:
(no structure information available)
guadinomic acid Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFU82605.1
  • gdnV
 1 - 1470 (+) protein phosphatase
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    • AFU82606.1
    • gdnW
    		 1525 - 2190 (-) integral membrane protein
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      • AFU82607.1
      • gdnX
      		 2513 - 4132 (-) lysyl tRNA synthetase
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        • AFU82608.1
        • gdnY
        		 4632 - 5393 (+) 2 component system response regulator
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          • AFU82609.1
          • gdnZ
          		 5453 - 6538 (+) 2 component system sensor kinase
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            • AFU82610.1
            • gdnA
            		 6615 - 7739 (-) acyl CoA dehydrogenase
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              • AFU82611.1
              • gdnB
              		 7744 - 8922 (-) seryl tRNA synthetase
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                • AFU82612.1
                • gdnC
                		 8951 - 9193 (-) acyl carrier protein
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                  • AFU82613.1
                  • gdnD
                  		 9212 - 10081 (-) 3 hydroxyacyl CoA dehydrogenase
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                    • AFU82614.1
                    • gdnE
                    		 10722 - 18092 (+) mixed NRPS PKS
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                      • AFU82615.1
                      • gdnF
                      		 18215 - 22627 (+) polyketide synthase
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                        • AFU82616.1
                        • gdnG
                        		 23506 - 29805 (+) polyketide synthase
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                          • AFU82617.1
                          • gdnH
                          		 29928 - 35975 (+) polyketide synthase
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                            • AFU82618.1
                            • gdnI
                            		 36206 - 36997 (+) 2-oxoglutarate dependent oxygenase
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                              • AFU82619.1
                              • gdnJ
                              		 37098 - 38180 (+) arginine:glycine amidinotransferase
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                                • AFU82620.1
                                • gdnK
                                		 38203 - 39930 (+) carbamoyltransferase
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                                  • AFU82621.1
                                  • gdnL
                                  		 40200 - 41168 (+) hypothetical protein
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                                    • AFU82622.1
                                    • gdnM
                                    		 41305 - 42189 (-) ABC type multidrug transport system, permease component
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                                      • AFU82623.1
                                      • gdnN
                                      		 42203 - 42961 (-) ABC type multidrug transport system, permease component
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                                        • AFU82624.1
                                        • gdnO
                                        		 43032 - 43985 (-) ABC transporter, ATPase component
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                                          • AFU82625.1
                                          • gdnP
                                          		 44372 - 45643 (+) Carbamoylphosphate synthetase large subunit
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                                            • AFU82626.1
                                            • gdnQ
                                            		 45940 - 46860 (+) rRNA methyltransferase
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                                              • AFU82627.1
                                              • gdnR
                                              		 46909 - 48159 (-) carbamoyl phosphate synthetase like protein
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                                                • AFU82628.1
                                                • gdnS
                                                		 48172 - 48834 (-) 4'-phosphopantetheinyl transferase
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                                                  • AFU82629.1
                                                  • gdnT
                                                  		 48951 - 49733 (-) thioesterase
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                                                    • AFU82630.1
                                                    • gdnU
                                                    		 49857 - 51101 (+) carbamoyl phosphate synthetase like protein
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                                                      Biosynthesis information
                                                      Annotation changelog

                                                      Entry version: 4

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-10-07
                                                      Update chemical activity to schema version 2.11
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 3

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-09-15
                                                      Linked new NPAtlas id for guadinomine (npatlas:NPA018300)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2022-09-15
                                                      Add new compound: guadinomine B
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2022-09-15
                                                      Add new compound: guadinomic acid
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2022-09-15
                                                      Updated bioactivity data
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 2

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2019-10-16
                                                      Migrated from v1.4
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 1

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2015-06-12
                                                      Submitted
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      Detailed domain annotation
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