BGC0000998: guadinomine biosynthetic gene cluster from Streptomyces sp. K01-0509
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Location: 1 - 51,101 nt. (total: 51,101 nt).
This entry is originally from NCBI GenBank JX545234.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000998
Short description guadinomine biosynthetic gene cluster from Streptomyces sp. K01-0509
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: JX545234.1
Compounds
  • guadinomine
  • guadinomine B
  • guadinomic acid
Species Streptomyces sp. K01-0509 [taxonomy]
References
Chemical products information
guadinomine
(no structure information available)
Chemical database entries
NPAtlas
guadinomine B
(no structure information available)
guadinomic acid
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFU82605.1
  • gdnV
 1 - 1470 (+) protein phosphatase
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  • AFU82606.1
  • gdnW
 1525 - 2190 (-) integral membrane protein
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  • AFU82607.1
  • gdnX
 2513 - 4132 (-) lysyl tRNA synthetase
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  • AFU82608.1
  • gdnY
 4632 - 5393 (+) 2 component system response regulator
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  • AFU82609.1
  • gdnZ
 5453 - 6538 (+) 2 component system sensor kinase
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  • AFU82610.1
  • gdnA
 6615 - 7739 (-) acyl CoA dehydrogenase
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  • AFU82611.1
  • gdnB
 7744 - 8922 (-) seryl tRNA synthetase
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  • AFU82612.1
  • gdnC
 8951 - 9193 (-) acyl carrier protein
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  • AFU82613.1
  • gdnD
 9212 - 10081 (-) 3 hydroxyacyl CoA dehydrogenase
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  • AFU82614.1
  • gdnE
 10722 - 18092 (+) mixed NRPS PKS
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  • AFU82615.1
  • gdnF
 18215 - 22627 (+) polyketide synthase
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  • AFU82616.1
  • gdnG
 23506 - 29805 (+) polyketide synthase
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  • AFU82617.1
  • gdnH
 29928 - 35975 (+) polyketide synthase
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  • AFU82618.1
  • gdnI
 36206 - 36997 (+) 2-oxoglutarate dependent oxygenase
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  • AFU82619.1
  • gdnJ
 37098 - 38180 (+) arginine:glycine amidinotransferase
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  • AFU82620.1
  • gdnK
 38203 - 39930 (+) carbamoyltransferase
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  • AFU82621.1
  • gdnL
 40200 - 41168 (+) hypothetical protein
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  • AFU82622.1
  • gdnM
 41305 - 42189 (-) ABC type multidrug transport system, permease component
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  • AFU82623.1
  • gdnN
 42203 - 42961 (-) ABC type multidrug transport system, permease component
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  • AFU82624.1
  • gdnO
 43032 - 43985 (-) ABC transporter, ATPase component
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  • AFU82625.1
  • gdnP
 44372 - 45643 (+) Carbamoylphosphate synthetase large subunit
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  • AFU82626.1
  • gdnQ
 45940 - 46860 (+) rRNA methyltransferase
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  • AFU82627.1
  • gdnR
 46909 - 48159 (-) carbamoyl phosphate synthetase like protein
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  • AFU82628.1
  • gdnS
 48172 - 48834 (-) 4'-phosphopantetheinyl transferase
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  • AFU82629.1
  • gdnT
 48951 - 49733 (-) thioesterase
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  • AFU82630.1
  • gdnU
 49857 - 51101 (+) carbamoyl phosphate synthetase like protein
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Linked new NPAtlas id for guadinomine (npatlas:NPA018300)
  • Add new compound: guadinomine B
  • Add new compound: guadinomic acid
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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