BGC0000998 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000998 (Streptomyces sp. K01-0509)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS-like	1	51,101	borrelidin	Polyketide:Modular type I	4%

BGC0000998 - Region 1 - NRPS-like,T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 51,101 nt. (total: 51,101 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 51,102
Label		BGC0000998

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000998.1	1.33	NRP, Polyketide	guadinomine	Streptomyces sp. K01-0509
BGC0000979.1	0.73	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	0.73	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0000003.1	0.57	Polyketide	AF-toxin	Alternaria alternata
BGC0000971.1	0.53	NRP, Polyketide	cinnabaramide A	Streptomyces cinnabarigriseus
BGC0000067.1	0.52	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000041.1	0.51	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001858.1	0.51	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001793.1	0.50	Polyketide	swainsonine	Chaetothyriaceae sp.
BGC0001068.1	0.50	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000998.1	0.90	NRP, Polyketide	guadinomine	Streptomyces sp. K01-0509
BGC0000979.1	0.68	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	0.68	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0001476.1	0.67	Other, , (, N, u, c, l, e, o, s, i, d, e, )	pseudouridimycin	Streptomyces sp.
BGC0001561.1	0.67	NRP	curacomycin	Streptomyces curacoi
BGC0000003.1	0.62	Polyketide	AF-toxin	Alternaria alternata
BGC0000971.1	0.61	NRP, Polyketide	cinnabaramide A	Streptomyces cinnabarigriseus
BGC0000046.1	0.61	Polyketide	depudecin	Alternaria brassicicola
BGC0000432.1	0.60	NRP	streptothricin	Streptomyces rochei
BGC0000067.1	0.59	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 51101:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - ccmal) + (ohmal) + (redmal) + (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

gdnE

Search NORINE for peptide: strict or relaxed

AMP-binding (34..439): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DfhFvtHdAK
Nearest Stachelhaus code:: pro
Stachelhaus code match:: 50% (weak)

PKS_AT (1170..1465): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 184.1
inactive: 146.4
Methoxymalonyl-CoA: 72.7
Methylmalonyl-CoA: 63.7
Propionyl-CoA: 46.3
2-Methylbutyryl-CoA: 34.8
Ethylmalonyl-CoA: 27.1
Isobutyryl-CoA: 22.9
CHC-CoA: 22.9
Benzoyl-CoA: 22.6
Acetyl-CoA: 21.3
trans-1,2-CPDA: 14.6
fatty_acid: 10.7
3-Methylbutyryl-CoA: 7.1

gdnF

PKS_AT (515..813): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 91.7%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.0
inactive: 147.2
Methoxymalonyl-CoA: 68.4
Methylmalonyl-CoA: 67.6
Propionyl-CoA: 59.3
Ethylmalonyl-CoA: 30.0
Isobutyryl-CoA: 29.1
Benzoyl-CoA: 26.7
2-Methylbutyryl-CoA: 23.8
trans-1,2-CPDA: 20.7
CHC-CoA: 19.6
Acetyl-CoA: 19.6
fatty_acid: 10.4
3-Methylbutyryl-CoA: 9.0

gdnG

PKS_AT (561..860): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.4
inactive: 136.5
Methylmalonyl-CoA: 79.6
Methoxymalonyl-CoA: 76.7
Propionyl-CoA: 62.4
Isobutyryl-CoA: 48.4
2-Methylbutyryl-CoA: 37.8
Benzoyl-CoA: 36.6
CHC-CoA: 34.5
Ethylmalonyl-CoA: 32.6
trans-1,2-CPDA: 26.9
Acetyl-CoA: 20.2
3-Methylbutyryl-CoA: 7.9
fatty_acid: 0.0

gdnH

PKS_AT (530..818): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 70.8%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 150.1
inactive: 105.8
Methoxymalonyl-CoA: 61.4
Methylmalonyl-CoA: 57.9
Propionyl-CoA: 46.3
Benzoyl-CoA: 29.5
trans-1,2-CPDA: 26.9
Isobutyryl-CoA: 26.2
CHC-CoA: 21.6
Ethylmalonyl-CoA: 21.1
2-Methylbutyryl-CoA: 20.9
Acetyl-CoA: 16.9
fatty_acid: 16.1
3-Methylbutyryl-CoA: 0.0