BGC0001008: maduropeptin biosynthetic gene cluster from Actinomadura madurae
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Location: 12,362 - 75,173 nt. (total: 62,812 nt).
This entry is originally from NCBI GenBank AY271660.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001008
Short description maduropeptin biosynthetic gene cluster from Actinomadura madurae
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Enediyine)
Loci NCBI GenBank: AY271660.2
Compounds
  • maduropeptin
Species Actinomadura madurae [taxonomy]
References
Chemical products information
maduropeptin
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C24H20Cl1N1O6
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABY66030.1
  • mdpA1
 12362 - 13396 (+) dTDP-1-glucose synthase
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  • ABY66029.1
  • mdpL
 13466 - 14848 (-) epoxidase
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  • ABY66028.1
  • mdpC8
 14931 - 15953 (-) Zn-dependent alcohol dehydrogenase
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  • ABY66027.1
  • mdpA4
 16169 - 17389 (+) C-methyltransferase
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  • ABY66026.1
  • mdpC3
 17470 - 19089 (-) monooxygenase
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  • ABY66025.1
  • mdpA3
 19106 - 20092 (-) glucuronic acid decarboxylase
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  • ABY66024.1
  • mdpA2
 20095 - 21438 (-) NDP glucose dehydrogenase
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  • ABY66023.1
  • mdpA5
 21450 - 22661 (-) aminotransferase
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  • ABY66022.1
  • mdpJ
 22658 - 23104 (-) unknown
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  • ABY66021.1
  • mdpD2
 23145 - 24329 (-) oxidoreductase
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  • ABY66020.1
  • mdpB1
 24584 - 25630 (+) C-methyltransferase
  • Tailoring (Methylation)
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  • ABY66019.1
  • mdpB
 25704 - 30947 (+) 6-methylsalicylic acid synthase
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  • ABY66018.1
  • mdpB2
 30944 - 32590 (+) CoA ligase
  • Activation / processing
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  • ABY66017.1
  • mdpB3
 32644 - 33501 (-) acetyltransferase/esterase
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  • ABY66016.1
  • mdpA6
 33498 - 34898 (-) glycosyltransferase
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  • ABY66015.1
  • mdpR4
 35059 - 35796 (+) DNA alkylation repair
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  • ABY66014.1
  • mdpU1
 35858 - 37087 (-) P450 oxidoreductase
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  • ABY66013.1
  • mdpU2
 37084 - 38229 (-) hypothetical protein
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  • ABY66012.1
  • mdpU3
 38243 - 39478 (-) P450 oxidoreductase
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  • ABY66011.1
  • mdpC7
 39512 - 40897 (-) aminotransferase
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  • ABY66010.1
  • mdpA
 41116 - 41619 (+) binding protein
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  • ABY66009.1
  • mdpR3
 42173 - 43750 (-) transmembrane efflux protein
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  • ABY66008.1
  • mdpH
 43877 - 45205 (-) hydroxylase
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  • ABY66007.1
  • mdpC5
 45557 - 46939 (-) type II condensation domain protein
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  • ABY66006.1
  • mdpC
 46957 - 48513 (-) halogenase
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  • ABY66005.1
  • mdpC4
 48638 - 50251 (-) MIO-containing aminomutase
  • Tailoring (Unknown)
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  • ABY66004.1
  • mdpC1
 50248 - 53595 (-) type II beta-Tyr adenylation domain protein
  • Activation / processing
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  • ABY66003.1
  • mdpC2
 53809 - 54096 (+) type II PCP domain protein
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  • ABY66002.1
  • mdpC6
 54160 - 54756 (-) O-methyltransferase
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  • ABY66001.1
  • mdpE11
 54864 - 55667 (-) unknown
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  • ABY66000.1
  • mdpM
 55742 - 56839 (-) unknown
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  • ABY65999.1
  • mdpE9
 56853 - 58511 (-) oxidoreductase
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  • ABY65998.1
  • mdpE8
 58508 - 59077 (-) unknown
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  • ABY65997.1
  • mdpR1
 59561 - 60574 (+) regulatory protein
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  • ABY65996.1
  • mdpR2
 60834 - 61589 (+) transcription regulatory protein
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  • AAQ17113.2
  • mdpE7
 61675 - 63069 (-) putative P450 hydroxylase
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  • AAQ17112.1
  • mdpE6
 63066 - 63617 (-) flavin reductase
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  • AAQ17111.1
  • mdpE10
 63614 - 64072 (-) type II thioesterase
  • Scaffold biosynthesis
Heterologous expression
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  • AAQ17110.2
  • mdpE
 64077 - 69911 (-) enediyne polyketide synthase
  • Scaffold biosynthesis
Activity assay
Heterologous expression
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  • AAQ17109.1
  • mdpE5
 69908 - 70900 (-) unknown
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  • AAQ17108.2
  • mdpE4
 70907 - 72943 (-) unknown
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  • AAQ17107.2
  • mdpE3
 72947 - 73849 (-) hypothetical protein
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  • ABY65995.1
  • mdpE2
 74178 - 75173 (-) unknown
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Polyketide-specific information
Subclass Enediyine
Starter unit Acetyl-CoA
Cyclic? yes
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
mdpE10
+
mdpE
+
mdpB 		Synthase subclass: Iterative type I/Enediyne type I
Thioesterases:
  • mdpE10 (Type II)
Iterative PKS type: Partially reducing, Unknown
Iteration counts: 7
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: E2T2HCM4X7QXVS4LL4JVBPPK, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Refined reference coordinates
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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