Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001008.1:
Cluster 1Polyketide185411

BGC0001008, maduropeptin biosynthetic gene cluster from Actinomadura madurae. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: maduropeptin
ChemSpider ID: 21805429
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Antibacterial, Antioxidant
Molecular target: DNA

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Enediyine (cyclic)
Polyketide synthase subclass:
Iterative type I / Enediyne type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
MDPE,MDPB
Iterative PKS subtype:
Partially reducing
Number of iterations:
7
Other
Thioesterase type:
Type II
Release / cyclization type:
Hydrolysis

Gene cluster description

maduropeptin (BGC0001008). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AY271660, positions 11790-75173. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Xiaohui Yan (The Scripps Research Institute)

Literature references

1. Van Lanen SG et al. (2007) Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis. J Am Chem Soc 129(43):13082-94. doi: 10.1021/ja073275o. Epub 2007
2. Zhang J et al. (2008) A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proc Natl Acad Sci U S A 105(5):1460-5. doi: 10.1073/pnas.0711625105.
3. Horsman GP et al. (2010) Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes. Proc Natl Acad Sci U S A 107(25):11331-5. doi:
4. Ling J et al. (2010) Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate. J Am Chem Soc 132(36):12534-6. doi: 10.1021/ja1050814.