BGC0001010: melithiazol A biosynthetic gene cluster from Melittangium lichenicola
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Location: 1 - 51,855 nt. (total: 51,855 nt).
This entry is originally from NCBI GenBank AJ557546.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001010
Short description melithiazol A biosynthetic gene cluster from Melittangium lichenicola
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
AJ557546.1
via Heterologous expression
Compounds
  • melithiazol A
Species Melittangium lichenicola [taxonomy]
References
Chemical products information
melithiazol A Evidence:
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C20H26N2O4S2
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAD89764.1
 1 - 253 (-) hypothetical protein
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    • CAD89765.1
    		 442 - 1488 (-) hypothetical protein
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      • CAD89766.1
      		 3093 - 4529 (-) hypothetical protein
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        • CAD89767.1
        		 6939 - 8291 (+) hypothetical protein
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          • CAD89768.1
          		 8857 - 9420 (+) hypothetical protein
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            • CAD89769.1
            		 10009 - 10707 (+) hypothetical protein
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              • CAD89770.1
              		 10704 - 12062 (+) hypothetical protein
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                • CAD89771.1
                		 12120 - 13082 (+) hypothetical protein
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                  • CAD89772.1
                  		 13098 - 13454 (-) hypothetical protein
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                    • CAD89773.1
                    • melB
                    		 13880 - 17032 (+) MelB protein
                    • Scaffold biosynthesis
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                    • CAD89774.1
                    • melC
                    		 17065 - 21036 (+) MelC protein
                    • Scaffold biosynthesis
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                    • CAD89775.1
                    • melD
                    		 21033 - 30887 (+) MelD protein
                    • Scaffold biosynthesis
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                    • CAD89776.1
                    • melE
                    		 30940 - 36678 (+) MelE protein
                    • Scaffold biosynthesis
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                    • CAD89777.1
                    • melF
                    		 36675 - 40757 (+) MelF protein
                    • Scaffold biosynthesis
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                    • CAD89778.1
                    • melG
                    		 40757 - 46000 (+) MelG protein
                    • Scaffold biosynthesis
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                    • CAD89779.1
                    • melH
                    		 46019 - 47008 (+) MelH protein
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                      • CAD89780.1
                      • melJ
                      		 47014 - 48021 (-) MelJ protein
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                        • CAD89781.1
                        • melK
                        		 48018 - 48923 (-) MelK protein
                        • Tailoring
                        • Heterologous expression
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                        • CAD89782.1
                        		 50068 - 51855 (+) hypothetical protein
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                          Biosynthesis information

                          Biosynthetic modules

                          Name
                          2
                          Type
                          nrps-type1
                          Genes
                          melC
                          Substrates
                          cysteine (evidence: Structure-based inference)
                          Integrated Monomers
                          Domains
                          condensation (Heterocyclization), adenylation, oxidase
                          Name
                          3
                          Type
                          nrps-type1
                          Genes
                          melD
                          Substrates
                          cysteine (evidence: Structure-based inference)
                          Integrated Monomers
                          Domains
                          condensation (Heterocyclization), adenylation, oxidase
                          Name
                          7
                          Type
                          nrps-type1
                          Genes
                          melG
                          Substrates
                          glycine (evidence: Structure-based inference)
                          Integrated Monomers
                          Domains
                          condensation (LCL), adenylation
                          Name
                          1
                          Type
                          pks-modular
                          Genes
                          melB
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                          Name
                          4
                          Type
                          pks-modular
                          Genes
                          melD
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                          Name
                          5
                          Type
                          pks-modular
                          Genes
                          melE
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                          Name
                          6
                          Type
                          pks-modular
                          Genes
                          melF
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                          Annotation changelog

                          Entry version: 4

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-10-07
                          Update chemical activity to schema version 2.11
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 3

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-09-15
                          Corrected NRP module activity
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Remove leading/trailing whitespace in gene identifiers
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Changed amino acid substrates to lower case
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 2

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2019-10-16
                          Migrated from v1.4
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2019-10-16
                          Updated compound(s) information (NPAtlas curation)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 1

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2015-06-12
                          Submitted
                          • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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