BGC0001018: micropeptin K139 biosynthetic gene cluster from Microcystis aeruginosa K-139
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Location: 1 - 33,711 nt. (total: 33,711 nt).
This entry is originally from NCBI GenBank AB481215.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001018
Short description micropeptin K139 biosynthetic gene cluster from Microcystis aeruginosa K-139
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AB481215.1
via
Compounds
  • micropeptin K139
Species Microcystis aeruginosa K-139 [taxonomy]
References
Chemical products information
micropeptin K139 Evidence:
Copy SMILES
C47H74N10O13
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAH22761.1
  • mcnF
 162 - 2231 (-) putative ABC transporter
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    • BAH22762.1
    • mcnA
    		 2804 - 6142 (+) nonribosomal peptide synthetase
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      • BAH22763.1
      • mcnB
      		 6145 - 9462 (+) nonribosomal peptide synthetase
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        • BAH22764.1
        • mcnC
        		 9459 - 23657 (+) nonribosomal peptide synthetase
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          • BAH22765.1
          • mcnE
          		 23920 - 28080 (+) nonribosomal peptide synthetase
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            • BAH22766.1
            		 28304 - 28837 (+) hypothetical protein
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              • BAH22767.1
              		 29850 - 30638 (+) putative methyltransferase
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                • BAH22768.1
                		 30796 - 31530 (+) putative acyl-carrier protein reductase
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                  Biosynthesis information

                  Biosynthetic modules

                  Name
                  Unk01
                  Type
                  nrps-type1
                  Genes
                  mcnA
                  Substrates
                  aspartic acid (evidence: Structure-based inference, Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  adenylation
                  Name
                  Unk02
                  Type
                  nrps-type1
                  Genes
                  mcnB
                  Substrates
                  threonine (evidence: ATP-PPi exchange assay, Structure-based inference, Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  adenylation
                  Name
                  Unk03
                  Type
                  nrps-type1
                  Genes
                  mcnC
                  Substrates
                  arginine (evidence: Structure-based inference, Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  adenylation
                  Name
                  Unk04
                  Type
                  nrps-type1
                  Genes
                  mcnC
                  Substrates
                  3-amino-6-hydroxy-2-piperidone (evidence: Structure-based inference, Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  adenylation
                  Name
                  Unk05
                  Type
                  nrps-type1
                  Genes
                  mcnC
                  Substrates
                  isoleucine (evidence: Structure-based inference, Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  adenylation
                  Name
                  Unk06
                  Type
                  nrps-type1
                  Genes
                  mcnC
                  Substrates
                  tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  adenylation
                  Name
                  Unk07
                  Type
                  nrps-type1
                  Genes
                  mcnE
                  Substrates
                  isoleucine (evidence: Structure-based inference, Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  adenylation
                  Annotation changelog

                  Entry version: 3

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-09-15
                  Removed erroneous polyketide class
                  • (ID: CUSGWVK3I4TVHJH7NHPFAP2L)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Added NRP substrate specificities
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 2

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2019-10-16
                  Migrated from v1.4
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 1

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2015-06-12
                  Submitted
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  Detailed domain annotation
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