BGC0001024: myxothiazol biosynthetic gene cluster from Stigmatella aurantiaca DW4/3-1
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Location: 1 - 42,603 nt. (total: 42,603 nt).
This entry is originally from NCBI GenBank AF188287.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001024
Short description myxothiazol biosynthetic gene cluster from Stigmatella aurantiaca DW4/3-1
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
AF188287.1
via Knock-out studies
Compounds
  • myxothiazol
Species Stigmatella aurantiaca DW4/3-1 [taxonomy]
References
Chemical products information
myxothiazol Evidence:
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C25H33N3O3S2
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAF19809.1
  • mtaA
 1 - 834 (+) MtaA
  • Activation / processing
  • Knock-out
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  • AAF19810.1
  • mtaB
 1388 - 13399 (+) MtaB
  • Scaffold biosynthesis
  • Knock-out
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  • AAF19811.1
  • mtaC
 13537 - 17409 (+) mtaC
  • Scaffold biosynthesis
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  • AAF19812.1
  • mtaD
 17406 - 27281 (+) MtaD
  • Scaffold biosynthesis
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  • AAF19813.1
  • mtaE
 27340 - 33183 (+) MtaE
  • Scaffold biosynthesis
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  • AAF19814.1
  • mtaF
 33188 - 37270 (+) MtaF
  • Scaffold biosynthesis
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  • AAF19815.1
  • mtaG
 37285 - 42537 (+) mtaG
  • Scaffold biosynthesis
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Biosynthesis information

Biosynthetic modules

Name
3
Type
nrps-type1
Genes
mtaC
Substrates
cysteine (evidence: Structure-based inference)
Integrated Monomers
Domains
condensation (Heterocyclization), adenylation, oxidase
Name
4
Type
nrps-type1
Genes
mtaD
Substrates
cysteine (evidence: )
Integrated Monomers
Domains
condensation (Heterocyclization), adenylation, oxidase
Name
8
Type
nrps-type1
Genes
mtaG
Substrates
glycine (evidence: Structure-based inference)
Integrated Monomers
Domains
condensation (LCL), adenylation
Name
1
Type
pks-modular
Genes
mtaB
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
Name
2
Type
pks-modular
Genes
mtaB
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
Name
5
Type
pks-modular
Genes
mtaD
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
Name
6
Type
pks-modular
Genes
mtaE
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
Name
7
Type
pks-modular
Genes
mtaF
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
Annotation changelog

Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Corrected NRP module activity
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Remove leading/trailing whitespace in gene identifiers
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2022-09-15
Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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2022-09-15
Changed amino acid substrates to lower case
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2019-10-16
Updated compound(s) information (NPAtlas curation)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted
  • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
Detailed domain annotation
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