Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001024.1:
Cluster 1NRP / Polyketide142603

BGC0001024, myxothiazol biosynthetic gene cluster from Stigmatella aurantiaca. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Myxothiazol
SMILES string: Copy to clipboard
Molecular formula: C25H33N3O3S2
Exact molecular mass: 488.2036 Da ([M+H]+)
Molecular activity: Antifungal, Cytotoxic
Molecular target: respiratory chain inhibitor BC-I complex

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
Type I
Release / cyclization type:
Other

Nonribosomal peptide synthetases:
mtaC (AAF19811.1)
Module 3
A specificity: Cysteine
Evidence for specificity: Structure-based inference
C domain subtype: Heterocyclization
Scaffold-modifying domain: Oxidation
mtaD (AAF19812.1)
Module 4
A specificity: Cysteine
Evidence for specificity: Other
C domain subtype: Heterocyclization
Scaffold-modifying domain: Oxidation
mtaG (AAF19815.1)
Module 8
A specificity: Glycine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
3-Methylbutyryl-CoA
Thioesterase type:
None
Release / cyclization type:
Other

Modular polyketide synthases:
mtaB (AAF19810.1)
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Module 2
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group

mtaD (AAF19812.1)
Module 5
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group

mtaE (AAF19813.1)
Module 6
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group

mtaF (AAF19814.1)
Module 7
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference

Gene cluster description

myxothiazol (BGC0001024). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank AF188287, positions 1-42603. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:No
Contact for this cluster:Daniel Krug (HIPS)

Literature references

1. Silakowski B et al. (1999) New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1. J Biol Chem 274(52):37391-9.