Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001049.1:
Cluster 1NRP / Polyketide121932

BGC0001049, tenellin biosynthetic gene cluster from Beauveria bassiana. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Tenellin
ChemSpider ID: 10207541
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (cyclic)
Thioesterase type:
Unknown
Release / cyclization type:
Other

Nonribosomal peptide synthetases:
tenS (CAL69597.1)
Module 2
A specificity: Tyrosine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module is non-elongating
Evidence for non-elongation: Unknown
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
Iterative PKS subtype:
Highly reducing
Number of iterations:
4
Other
Thioesterase type:
None
Release / cyclization type:
Other

Modular polyketide synthases:
tenS (CAL69597.1)
Module 1
AT specificity: Acetyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: Methylation
Module is iterated
Evidence for iteration: Unknown

Gene cluster description

tenellin (BGC0001049). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank AM409327, positions 1-21932. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Russell Cox (Leibniz Universitaet Hannover, Institut fuer Organische Chemie)

Literature references

1. Fisch KM et al. (2011) Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite. J Am Chem Soc 133(41):16635-41. doi: 10.1021/ja206914q. Epub 2011
2. Yakasai AA et al. (2011) Nongenetic reprogramming of a fungal highly reducing polyketide synthase. J Am Chem Soc 133(28):10990-8. doi: 10.1021/ja204200x. Epub 2011 Jun
3. Heneghan MN et al. (2010) First heterologous reconstruction of a complete functional fungal biosynthetic multigene cluster. Chembiochem 11(11):1508-12. doi: 10.1002/cbic.201000259.
4. Halo LM et al. (2008) Late stage oxidations during the biosynthesis of the 2-pyridone tenellin in the entomopathogenic fungus Beauveria bassiana. J Am Chem Soc 130(52):17988-96. doi: 10.1021/ja807052c.
5. Eley KL et al. (2007) Biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus Beauveria bassiana. Chembiochem 8(3):289-97. doi: 10.1002/cbic.200600398.
6. Halo LM et al. (2008) Authentic heterologous expression of the tenellin iterative polyketide synthase nonribosomal peptide synthetase requires coexpression with an enoyl reductase. Chembiochem 9(4):585-94. doi: 10.1002/cbic.200700390.