Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001053.1:
Cluster 1NRP / Polyketide182868

BGC0001053, tubulysin biosynthetic gene cluster from Angiococcus disciformis. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: tubulysin
PubChem ID: 12134544
SMILES string: Copy to clipboard
Molecular formula: C43H65N5O10S
Average molecular mass: 844.078 Da

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Polyketide synthase subclass:
Type I

Gene cluster description

tubulysin (BGC0001053). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank AJ620477. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

Literature references

1. Sandmann A et al. (2004) Identification and analysis of the core biosynthetic machinery of tubulysin, a potent cytotoxin with potential anticancer activity. Chem Biol 11(8):1071-9. doi: 10.1016/j.chembiol.2004.05.014.