Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001054.1:
Cluster 1NRP / Polyketide141309

BGC0001054, xenocoumacin biosynthetic gene cluster from Xenorhabdus nematophila. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Xenocoumacin 1
PubChem ID: 163752
SMILES string: Copy to clipboard
Molecular formula: C22H35N5O6
Average molecular mass: 465.551 Da
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
Type II
Release / cyclization type:
Unknown

Nonribosomal peptide synthetases:
xcnA (XNC1_1711)
Module 3
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Unknown
Module 4
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Unknown
xcnK (XNC1_1701)
Module 1
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Unknown
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Unknown
Thioesterase type:
Type II
Release / cyclization type:
Unknown

Modular polyketide synthases:
xcnH (XNC1_1704)
Module 7
AT specificity: Unknown
Evidence for specificity: Unknown
KR stereochemistry: Unknown

xcnL (XNC1_1700)
Module 2
AT specificity: Unknown
Evidence for specificity: Unknown
KR stereochemistry: Unknown

xcnF (XNC1_1706)
Module 5
AT specificity: Unknown
Evidence for specificity: Unknown
KR stereochemistry: Unknown
Module 6
AT specificity: Unknown
Evidence for specificity: Unknown

Gene cluster description

xenocoumacin (BGC0001054). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank FN667742, positions 1572674-1613982. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Helge Bode (Goethe Universitaet Frankfurt)

Literature references

1. Park D et al. (2009) Genetic analysis of xenocoumacin antibiotic production in the mutualistic bacterium Xenorhabdus nematophila. Mol Microbiol 73(5):938-49. doi: 10.1111/j.1365-2958.2009.06817.x. Epub
2. Reimer D et al. (2009) A new type of pyrrolidine biosynthesis is involved in the late steps of xenocoumacin production in Xenorhabdus nematophila. Chembiochem 10(12):1997-2001. doi: 10.1002/cbic.200900187.
3. Lang G et al. (2008) Linear and cyclic peptides from the entomopathogenic bacterium Xenorhabdus nematophilus. J Nat Prod 71(6):1074-7. doi: 10.1021/np800053n. Epub 2008 May 21.