BGC0001057 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001057 (Fusarium graminearum (Gibberella zeae))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	1	49,993	trans-resorcylide	Polyketide	33%

BGC0001057 - Region 1 - NRPS,T1PKS

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Location: 1 - 49,993 nt. (total: 49,993 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 49,994
Label		BGC0001057

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001057.1	1.39	NRP, Polyketide	zearalenone	Fusarium graminearum
BGC0000900.1	0.68	Other	ferrichrome	Aspergillus oryzae
BGC0001249.1	0.68	NRP	dimethylcoprogen	Alternaria alternata
BGC0000046.1	0.64	Polyketide	depudecin	Alternaria brassicicola
BGC0001909.1	0.64	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001068.1	0.58	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001858.1	0.58	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001718.1	0.57	NRP	okaramine D	Aspergillus aculeatus ATCC 16872
BGC0000979.1	0.57	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	0.57	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001057.1	0.91	NRP, Polyketide	zearalenone	Fusarium graminearum
BGC0000900.1	0.67	Other	ferrichrome	Aspergillus oryzae
BGC0001249.1	0.67	NRP	dimethylcoprogen	Alternaria alternata
BGC0000046.1	0.65	Polyketide	depudecin	Alternaria brassicicola
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001068.1	0.63	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001858.1	0.62	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001718.1	0.62	NRP	okaramine D	Aspergillus aculeatus ATCC 16872
BGC0000979.1	0.62	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	0.62	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 49993:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk) + (mal) + (X - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 36031:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk) + (mal) + (X - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 205 - 49993:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk) + (mal) + (X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

NPS

Search NORINE for peptide: strict or relaxed

AMP-binding (221..620): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: dvsnlstfkk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AMP-binding (1301..1695): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: dvlcvawlsk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

PKS13

PKS_AT (887..1182): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Methylmalonyl-CoA: 58.3%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 109.8
Methoxymalonyl-CoA: 69.9
Methylmalonyl-CoA: 65.2
inactive: 58.0
Isobutyryl-CoA: 44.8
Propionyl-CoA: 36.3
Benzoyl-CoA: 34.8
Ethylmalonyl-CoA: 32.2
2-Methylbutyryl-CoA: 30.3
Acetyl-CoA: 29.1
CHC-CoA: 23.7
fatty_acid: 20.1
3-Methylbutyryl-CoA: 19.9
trans-1,2-CPDA: 19.1

PKS4

PKS_AT (537..838): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; Methylmalonyl-CoA: 66.7%; Ethylmalonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 92.7
Methoxymalonyl-CoA: 81.6
Malonyl-CoA: 72.7
Ethylmalonyl-CoA: 57.3
Isobutyryl-CoA: 53.6
Propionyl-CoA: 38.5
Benzoyl-CoA: 35.8
CHC-CoA: 25.8
trans-1,2-CPDA: 22.9
fatty_acid: 22.3
Acetyl-CoA: 21.1
2-Methylbutyryl-CoA: 19.1
3-Methylbutyryl-CoA: 12.0
inactive: 11.3