Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001061.1:
Cluster 1Polyketide / Saccharide152164

BGC0001061, polyketomycin biosynthetic gene cluster from Streptomyces diastatochromogenes. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Polyketomycin
ChEBI ID: 66771
SMILES string: Copy to clipboard
Molecular formula: C44H48O18
Average molecular mass: 864.84110 Da
Molecular activity: Antibacterial, Cytotoxic

Class-specific details

Biosynthetic class(es):
Polyketide / Saccharide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Iterative type I / Type II
Starter unit:
Malonyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
ACN64836.1,ACN64834.1
Iterative PKS subtype:
Partially reducing
Number of iterations:
9
Iterative PKS cyclization type:
Other
ACN64848.1, ACN64846.1, ACN64851.1
Thioesterase type:
Unknown
Release / cyclization type:
Unknown

Modular polyketide synthases:
pokM1 (ACN64831.1)
Module 1
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Unknown

Gene cluster description

polyketomycin (BGC0001061). Gene Cluster 1. Biosynthetic class = Polyketide/Saccharide. GenBank FJ483966. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Andreas Bechthold (Albert-Ludwigs-University of Freiburg, Germany)

Literature references

1. Momose I et al. (1998) Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo) 51(1):21-5.
2. Momose I et al. (1998) Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. II. Structure determination. J Antibiot (Tokyo) 51(1):26-32.
3. Paululat T et al. (1999) Biosynthesis of polyketomycin produced by Streptomyces diastatochromogenes Tu 6028. J Antibiot (Tokyo) 52(2):96-101.
4. Daum M et al. (2009) Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem 10(6):1073-83. doi: 10.1002/cbic.200800823.