BGC0001061 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001061 (Streptomyces diastatochromogenes)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS,T1PKS,PKS-like	1	52,164	dutomycin	Polyketide	79%

BGC0001061 - Region 1 - PKS-like,T1PKS,T2PKS

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Location: 1 - 52,164 nt. (total: 52,164 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
PKS-like: (t2pks2 or ksIII)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 52,165
Label		BGC0001061

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001061.1	1.75	Polyketide, Saccharide	polyketomycin	Streptomyces diastatochromogenes
BGC0000248.1	1.29	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000231.1	1.02	Polyketide	griseusin	Streptomyces griseus
BGC0001909.1	0.97	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000228.1	0.93	Polyketide	granaticin	Streptomyces violaceoruber
BGC0001409.1	0.88	Polyketide	dutomycin	Streptomyces minoensis
BGC0000272.1	0.83	Polyketide	spore pigment	Streptomyces collinus
BGC0000065.1	0.81	Polyketide	rustmicin	Streptomyces galbus
BGC0001797.1	0.80	RiPP	telomestatin	Streptomyces anulatus
BGC0000046.1	0.79	Polyketide	depudecin	Alternaria brassicicola

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001061.1	0.87	Polyketide, Saccharide	polyketomycin	Streptomyces diastatochromogenes
BGC0000248.1	0.74	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000231.1	0.66	Polyketide	griseusin	Streptomyces griseus
BGC0001409.1	0.66	Polyketide	dutomycin	Streptomyces minoensis
BGC0001909.1	0.66	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000228.1	0.65	Polyketide	granaticin	Streptomyces violaceoruber
BGC0000065.1	0.63	Polyketide	rustmicin	Streptomyces galbus
BGC0000272.1	0.61	Polyketide	spore pigment	Streptomyces collinus
BGC0001983.1	0.61	Other	triacsins	Kitasatospora aureofaciens
BGC0001281.1	0.60	Polyketide	ustilagic acid	Ustilago maydis 521

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Type II PKS

Predicted core structure(s)

For candidate cluster 1, location 0 - 52164:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 44665:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

pokM3

Search NORINE for peptide: strict or relaxed

AMP-binding (33..447): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: PLPshGViCK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 70% (weak)

pokM1

PKS_AT (543..835): mmal

ATSignature: Malonyl-CoA, Methylmalonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 79.2%; Ethylmalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 122.6
Ethylmalonyl-CoA: 104.9
Methoxymalonyl-CoA: 99.8
Malonyl-CoA: 88.7
Propionyl-CoA: 68.0
Isobutyryl-CoA: 65.4
2-Methylbutyryl-CoA: 58.3
Acetyl-CoA: 43.8
3-Methylbutyryl-CoA: 41.7
Benzoyl-CoA: 41.0
trans-1,2-CPDA: 35.2
CHC-CoA: 32.1
inactive: 30.8
fatty_acid: 27.8

pokL

Search NORINE for peptide: strict or relaxed

AMP-binding (15..392): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: leu

Stachelhaus prediction details:

Stachelhaus sequence:: --mYFGGpmK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 50% (weak)

Type II PKS gene cluster prediction details

Cluster section:: 0 to 52164
Starter unit(s):: malonamyl-CoA (Score: 424.0; E-value: 7.02e-148)
Malonyl elongations:: 8|9 (Score: 645.0; E-value: 9.3e-197)
Product class(es):: anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: malonamyl-CoA_8: 815.81 Da
malonamyl-CoA_9: 857.85 Da

pokC1: CYC C1-C18|C2-C19 (Score: 230.6; E-value: 1.3e-71)
pokC2: CYC C5-C14/C3-C16 (Score: 443.4; E-value: 5.6e-136)
pokC3: CYC C7-C12 (Score: 327.2; E-value: 1.8e-100)
pokGT1: GT (Score: 386.7; E-value: 3.6e-118)
pokGT2: GT (Score: 347.0; E-value: 4.3e-106)
pokL: LIG (Score: 503.9; E-value: 9.1e-154); LIG ADE34493.1_SF2575_malonamyl-CoA (Score: 424.0; E-value: 7.02e-148)
pokMT1: MET (Score: 180.1; E-value: 1.5e-55)
pokMT2: MET C6|C8 (Score: 553.4; E-value: 3.5e-169)
pokMT3: MET C11O (Score: 471.3; E-value: 3.5e-144)
pokO1: OXY (Score: 193.6; E-value: 1.5e-59)
pokO2: OXY (Score: 395.4; E-value: 9.2e-121)
pokO4: OXY (Score: 479.1; E-value: 3.8e-146)
pokP1: KS (Score: 771.2; E-value: 5.5e-235)
pokP2: CLF 8|9 (Score: 645.0; E-value: 9.3e-197)
pokP3: ACP (Score: 107.2; E-value: 7.3e-34)
pokT1: KR (Score: 127.5; E-value: 1.7e-39)
pokT2: KR (Score: 193.2; E-value: 1.5e-59)