BGC0001067: Fumagillin biosynthetic gene cluster from Aspergillus fumigatus Af293
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Location: 79,285 - 114,438 nt. (total: 35,154 nt).
This entry is originally from NCBI GenBank CM000176.1.

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Gene details
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General
Compounds
Genes
Polyketide
Terpene
History
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001067
Short description Fumagillin biosynthetic gene cluster from Aspergillus fumigatus Af293
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Polyene)
  • Terpene (Sesquiterpene/Unknown)
Loci NCBI GenBank: CM000176.1
Compounds
  • Fumagillin
  • beta-trans-bergamotene
  • fumagillol
Species Aspergillus fumigatus Af293 [taxonomy]
References
Chemical products information
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Fumagillin [synonyms]
Molecular Formula C26H4O7
Chemical database entries NPAtlas   PubCHEM  
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beta-trans-bergamotene [synonyms]
Molecular Formula C16H2
Chemical database entries PubCHEM  
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fumagillol [synonyms]
Molecular Formula C16H4O6
Chemical database entries PubCHEM  
List of genes involved in compound(s) production
Identifiers Position Product Functions Extra
  • AFUA_8G00370
  • EAL85129.1
79285 86887 - polyketide synthase
  • Scaffold biosynthesis (evidence: KAO)
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  • AFUA_8G00380
  • EAL85128.1
87370 88295 + acyltransferase
  • Scaffold biosynthesis (evidence: KAO)
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  • AFUA_8G00390
  • EAL85127.1
88492 89296 - O-methyltransferase
  • Tailoring (Methylation) (evidence: KAO)
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  • AFUA_8G00400
  • EAL85126.1
89383 89870 - conserved hypothetical protein
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  • AFUA_8G00410
  • EAL85125.1
90299 92235 - methionine aminopeptidase, type II, putative
  • Unknown (evidence: K)
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  • AFUA_8G00420
  • EAL85124.1
93113 95101 + C6 finger transcription factor
  • Regulation (evidence: K)
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  • AFUA_8G00430
  • EAL85123.1
95277 95807 - conserved hypothetical protein
  • Unknown (evidence: K)
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  • AFUA_8G00440
  • EAL85122.1
96252 98969 - steroid monooxygenase, putative
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  • AFUA_8G00460
  • EAL85121.1
100917 102341 + methionine aminopeptidase, type I, putative
  • Unknown (evidence: K)
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  • AFUA_8G00470
  • EAL85120.1
102474 103368 - ABM superfamily monooxygenase
  • Tailoring (Oxidation) (evidence: KAO)
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  • AFUA_8G00480
  • EAL85119.2
103765 104694 + hydroxylase
  • Tailoring (Hydroxylation) (evidence: KAO)
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  • AFUA_8G00490
  • EAL85118.1
105095 108249 + PKS-like enzyme, ketoreductase
  • Tailoring (Reduction) (evidence: KAO)
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  • AFUA_8G00500
  • EAL85117.1
108297 110523 - acetate-CoA ligase, putative
  • Unknown (evidence: K)
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  • AFUA_8G00510
  • EAL85116.1
110932 112596 - cytochrome P450 oxidoreductase
  • Tailoring (Oxidation) (evidence: KAO)
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  • AFUA_8G00520
  • EAL85115.1
113744 114438 + terpene cycase
  • Scaffold biosynthesis (evidence: KAO)
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Polyketide-specific information
Subclass Polyene
Starter unit Acetyl-CoA
Cyclic? no
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
EAL85129.1
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EAL85129.1
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EAL85128.1
Synthase subclass: Iterative type I
Thioesterases:
  • EAL85128.1 (Unknown)
Iterative PKS type: Highly reducing, Unknown
Iteration counts: 5
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Activity assay
Genes: EAL85129.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Activity assay
Terpene-specific information
Subclass Sesquiterpene / Unknown
Isoprenoid precursor FPP
Terpene synthases/cyclases EAL85115.1
Annotation changelog
MIBiG version Notes
2.0
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
Detailed domain annotation
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