BGC0001067: fumagillin biosynthetic gene cluster from Aspergillus fumigatus Af293
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Location: 79,285 - 114,438 nt. (total: 35,154 nt).
This entry is originally from NCBI GenBank CM000176.1.

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core biosynthetic genes
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General
Compounds
Genes
Polyketide
Terpene
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001067
Short description fumagillin biosynthetic gene cluster from Aspergillus fumigatus Af293
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Polyene)
  • Terpene (Sesquiterpene/Unknown)
Loci NCBI GenBank: CM000176.1
Compounds
  • fumagillin
  • β-trans-bergamotene
  • fumagillol
Species Aspergillus fumigatus Af293 [taxonomy]
References
Chemical products information
fumagillin [synonyms: amebacilin, fugillin, fumidil]
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C26H34O7
Chemical database entries
NPAtlas
PubCHEM
β-trans-bergamotene [synonyms: exo-beta-bergamotene, trans-beta-bergamotene, (+)-exo-beta-bergamotene]
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C15H24
Chemical database entries
PubCHEM
fumagillol [synonyms: alcohol-i from fumagillin, gelcohol]
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C16H26O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFUA_8G00370
  • EAL85129.1
 79285 - 86887 (-) polyketide synthase
  • Scaffold biosynthesis
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  • AFUA_8G00380
  • EAL85128.1
 87370 - 88295 (+) acyltransferase
  • Scaffold biosynthesis
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  • AFUA_8G00390
  • EAL85127.1
 88492 - 89296 (-) O-methyltransferase
  • Tailoring (Methylation)
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  • AFUA_8G00400
  • EAL85126.1
 89383 - 89870 (-) conserved hypothetical protein
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  • AFUA_8G00410
  • EAL85125.1
 90299 - 92235 (-) methionine aminopeptidase, type II, putative
  • Unknown
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  • AFUA_8G00420
  • EAL85124.1
 93113 - 95101 (+) C6 finger transcription factor
  • Regulation
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  • AFUA_8G00430
  • EAL85123.1
 95277 - 95807 (-) conserved hypothetical protein
  • Unknown
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  • AFUA_8G00440
  • EAL85122.1
 96252 - 98969 (-) steroid monooxygenase, putative
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  • AFUA_8G00460
  • EAL85121.1
 100917 - 102341 (+) methionine aminopeptidase, type I, putative
  • Unknown
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  • AFUA_8G00470
  • EAL85120.1
 102474 - 103368 (-) ABM superfamily monooxygenase
  • Tailoring (Oxidation)
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  • AFUA_8G00480
  • EAL85119.2
 103765 - 104694 (+) hydroxylase
  • Tailoring (Hydroxylation)
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  • AFUA_8G00490
  • EAL85118.1
 105095 - 108249 (+) PKS-like enzyme, ketoreductase
  • Tailoring (Reduction)
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  • AFUA_8G00500
  • EAL85117.1
 108297 - 110523 (-) acetate-CoA ligase, putative
  • Unknown
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  • AFUA_8G00510
  • EAL85116.1
 110932 - 112596 (-) cytochrome P450 oxidoreductase
  • Tailoring (Oxidation)
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  • AFUA_8G00520
  • EAL85115.1
 113744 - 114438 (+) terpene cycase
  • Scaffold biosynthesis
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Polyketide-specific information
Subclass Polyene
Starter unit Acetyl-CoA
Cyclic? no
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
AFUA_8G00370
+
AFUA_8G00370
+
AFUA_8G00380 		Synthase subclass: Iterative type I
Thioesterases:
  • AFUA_8G00380 (Unknown)
Iterative PKS type: Highly reducing, Unknown
Iteration counts: 5
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Activity assay
Genes: AFUA_8G00370
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Activity assay
Terpene-specific information
Carbon count subclass Sesquiterpene
Structural subclass Unknown
Isoprenoid precursor FPP
Terpene synthases/cyclases AFUA_8G00520
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: BMUFDHMMOLZWQLUNJMQED2GP, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Add additional publications
  • Removed gene names of 'No gene ID'
  • Trimmed gene names containing multiple alternatives
  • Cleaned up synonym list
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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