BGC0001067 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001067 (Aspergillus fumigatus Af293)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	35,154

BGC0001067 - Region 1 - T1PKS

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Location: 1 - 35,154 nt. (total: 35,154 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 35,155
Label		BGC0001067

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001067.1	0.47	Polyketide, Terpene	fumagillin, β-trans-bergamotene, fumagillol	Aspergillus fumigatus Af293
BGC0001858.1	0.29	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001280.1	0.26	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.26	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001068.1	0.25	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000003.1	0.23	Polyketide	AF-toxin	Alternaria alternata
BGC0000046.1	0.23	Polyketide	depudecin	Alternaria brassicicola
BGC0001909.1	0.23	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001252.1	0.22	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0001124.1	0.21	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001067.1	0.79	Polyketide, Terpene	fumagillin, β-trans-bergamotene, fumagillol	Aspergillus fumigatus Af293
BGC0001858.1	0.63	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001280.1	0.59	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.59	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001068.1	0.58	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000003.1	0.57	Polyketide	AF-toxin	Alternaria alternata
BGC0000046.1	0.57	Polyketide	depudecin	Alternaria brassicicola
BGC0001909.1	0.56	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001252.1	0.55	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0001124.1	0.54	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015

Similar known gene clusters

No matches found.

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 27603:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AFUA_8G00370

PKS_AT (597..911): mmal

ATSignature: Malonyl-CoA, Methylmalonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 75.0%; Ethylmalonyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 86.5
Methoxymalonyl-CoA: 83.2
Malonyl-CoA: 72.0
Isobutyryl-CoA: 59.0
Propionyl-CoA: 44.6
Ethylmalonyl-CoA: 33.8
2-Methylbutyryl-CoA: 29.2
3-Methylbutyryl-CoA: 28.9
Benzoyl-CoA: 18.7
Acetyl-CoA: 16.0
trans-1,2-CPDA: 15.1
fatty_acid: 15.1
inactive: 13.2
CHC-CoA: 10.8

AFUA_8G00500

Search NORINE for peptide: strict or relaxed

AMP-binding (74..567): X

NRPSPredictor2: gly, ala, val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: vvyffanspk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)