BGC0001073 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001073 (Micromonospora sp. TP-A0468)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS,ectoine	1	82,504	High	kosinostatin	NRPS:Type I+PKS

BGC0001073 - Region 1 - T2PKS,ectoine

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Location: 1 - 82,504 nt. (total: 82,504 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)
ectoine: ectoine_synt

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 82,505
Label		BGC0001073

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxidoreductase oxygenase

AFJ52665.1: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

AFJ52671.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AFJ52673.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AFJ52683.1: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

AFJ52691.1: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

AFJ52692.1: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

AFJ52697.1: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Transferases: glycosyltransferase methyltransferase transferase

AFJ52669.1: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

AFJ52684.1: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

AFJ52698.1: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: hydrolase

AFJ52696.1: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Lyases: cyclase dehydratase

AFJ52670.1: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

AFJ52672.1: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: ligase synthase

AFJ52660.1: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

AFJ52674.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

AFJ52675.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

AFJ52687.1: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001073.5	1.22	NRPS, PKS	kosinostatin	Micromonospora sp. TP-A0468
BGC0002097.3	0.70	NRPS, PKS, saccharide	kosinostatin	Micromonospora sp. 28ISP2-46
BGC0000231.5	0.45	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001778.5	0.42	other (other)	showdomycin	Streptomyces showdoensis
BGC0000852.5	0.36	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.35	other (other)	ectoine	Methylobacter marinus
BGC0000855.3	0.35	other (other)	ectoine	Methylomicrobium kenyense
BGC0000234.5	0.34	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002276.2	0.32	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001723.5	0.31	PKS	oviedomycin	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001073.5	0.99	NRPS, PKS	kosinostatin	Micromonospora sp. TP-A0468
BGC0002097.3	0.81	NRPS, PKS, saccharide	kosinostatin	Micromonospora sp. 28ISP2-46
BGC0000231.5	0.76	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.67	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002276.2	0.65	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001723.5	0.65	PKS	oviedomycin	Streptomyces antibioticus
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0000218.5	0.60	PKS	doxorubicin	Streptomyces peucetius
BGC0000235.5	0.59	PKS	kiamycin	Streptomyces sp. W007
BGC0002477.3	0.59	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

AFJ52660.1: X

AMP-binding (12..417): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLLQVTLDSK
Nearest Stachelhaus code(s):: Ala DILQITLVYK (44% 8Å match)
Stachelhaus code match:: 60% (weak)

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 61519
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 657.3; E-value: 1.7e-200)
Product class(es):: anthracycline
Product molecular weight(s):: acetyl-CoA_8: 498 Da
acetyl-CoA_9: 540 Da

AFJ52659.1: CYC C5-C14/C3-C16 (Score: 440.3; E-value: 4.9e-135)
AFJ52671.1: KR C17 (Score: 393.5; E-value: 8.4e-121)
AFJ52672.1: CYC C7-C12 (Score: 482.9; E-value: 7.7e-148)
AFJ52673.1: KR C9 (Score: 461.6; E-value: 1.6e-141)
AFJ52674.1: KS (Score: 777.8; E-value: 5.4e-237)
AFJ52675.1: CLF 8|9 (Score: 657.3; E-value: 1.7e-200)
AFJ52676.1: ACP (Score: 113.7; E-value: 6.9e-36)
AFJ52677.1: CYC C2-C19 (Score: 284.5; E-value: 2.8e-88)
AFJ52679.1: DIMER (Score: 288.1; E-value: 1.6e-88)
AFJ52681.1: CYC C1-C18|C2-C19 (Score: 193.7; E-value: 2.8e-60)
AFJ52684.1: GT (Score: 442.8; E-value: 3.3e-135)
AFJ52698.1: MET carboxy_O (Score: 372.6; E-value: 2e-114)