BGC0001082: Paxilline biosynthetic gene cluster from Penicillium paxilli
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Location: 28,174 - 46,982 nt. (total: 18,809 nt).
This entry is originally from NCBI GenBank HM171111.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001082
Short description Paxilline biosynthetic gene cluster from Penicillium paxilli
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • terpene (Hemiterpene)
Loci
HM171111.1
28174 - 46982
via Knock-out studies
Compounds
  • Paxilline
  • 21,22-diprenylated paxilline
Species Penicillium paxilli [taxonomy]
References
Chemical products information
Paxilline Evidence: NMR [2], Experimental values match with authentic standard [2]
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C27H33N1O4
Chemical database entries
NPAtlas
21,22-diprenylated paxilline Evidence: NMR [1], Mass spectrometry [1]
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List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAK11531.1
  • paxG
 28174 - 29467 (-) Geranylgeranyl diphosphate synthase
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    • ADO29933.1
    • paxA
    		 30010 - 31140 (-) Integral membrane protein
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      • AAK11530.1
      • paxM
      		 31893 - 33451 (-) FAD-dependent monooxygenase
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        • ADO29934.1
        • paxB
        		 33931 - 34749 (-) Indole-diterpene cyclase
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          • AAK11529.1
          • paxC
          		 35815 - 36891 (+) Prenyltransferase (attaches GGPP to indole)
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            • AAK11528.1
            • paxP
            		 37431 - 39279 (-) Cytochrome P450 monooxygenase
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              • AAK11527.1
              • paxQ
              		 41665 - 43751 (-) Cytochrome P450 monooxygenase
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                • AAK11526.2
                • paxD
                		 45576 - 46982 (-) Prenyltransferase (prenylates paxilline at position 21 and 22)
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                  Biosynthesis information
                  Annotation changelog

                  Entry version: next

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2024-05-31
                  MIBiG v4 annotathon
                  • (ID: D44UGPXERIZAXNCG2VXZP5I3)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 3

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-10-07
                  Update chemical activity to schema version 2.11
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 2

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2019-10-16
                  Migrated from v1.4
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2019-10-16
                  Updated compound(s) information (NPAtlas curation)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 1

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2015-06-12
                  Submitted
                  • (ID: SBJKEFYKII5HH67NUPKPNDOM)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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