BGC0001118: endocrocin biosynthetic gene cluster from Aspergillus fumigatus Af293
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Location: 54,334 - 75,724 nt. (total: 21,391 nt).
This entry is originally from NCBI GenBank CM000172.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001118
Short description endocrocin biosynthetic gene cluster from Aspergillus fumigatus Af293
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Iterative type I)
Loci
CM000172.1
54334 - 75724
via Knock-out studies, Gene expression correlated with compound production
Compounds
  • endocrocin
Species Aspergillus fumigatus Af293 [taxonomy]
References
Chemical products information
endocrocin Evidence:
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C16H10O7
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFUA_4G00200
  • EAL84398.1
 54334 - 55733 (+) F-box domain protein
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    • AFUA_4G00210
    • EAL84397.1
    		 55988 - 61485 (-) polyketide synthase
    • Precursor biosynthesis
    • Knock-out
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    • AFUA_4G00220
    • EAL84396.1
    		 61850 - 62856 (-) metallo-beta-lactamase
    • Scaffold biosynthesis
    • Knock-out
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    • AFUA_4G00225
    • EBA27176.1
    		 63169 - 63795 (+) monooxygenase
    • Tailoring
    • Knock-out
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    • AFUA_4G00230
    • EAL84395.2
    		 64101 - 65225 (-) oxidoreductase
    • Tailoring
    • Knock-out
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    • AFUA_4G00235
    • EBA27175.1
    		 65900 - 66243 (+) conserved hypothetical protein
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      • AFUA_4G00240
      • EAL84394.2
      		 66688 - 68953 (-) amino acid transporter, putative
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        • AFUA_4G00250
        • EAL84393.2
        		 69578 - 73261 (+) WD40 repeat protein
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          • AFUA_4G00260
          • EAL84392.2
          		 73816 - 75724 (-) MFS transporter, putative
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            Biosynthesis information

            Biosynthetic modules

            Name
            1
            Type
            pks-modular
            Genes
            AFUA_4G00210
            Substrates
            Integrated Monomers
            Domains
            acyltransferase, ketosynthase, acyltransferase, product_template, carrier (ACP), carrier (ACP)
            Annotation changelog

            Entry version: 4

            Date
            Changes
            Submitters
            Reviewers
            2022-10-07
            Update chemical activity to schema version 2.11
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 3

            Date
            Changes
            Submitters
            Reviewers
            2022-09-15
            Removed ketoreductase stereochemistry annotation from modules without ketoreductases
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Corrected gene identifiers
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 2

            Date
            Changes
            Submitters
            Reviewers
            2019-10-16
            Migrated from v1.4
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 1

            Date
            Changes
            Submitters
            Reviewers
            2015-06-12
            Submitted
            • (ID: J4R6BDENZAM7XVDGVEEHZB2Y)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            Detailed domain annotation
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