BGC0001123 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001123 (Aspergillus oryzae RIB40)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS	1	57,817	High	aspirochlorine	NRPS:Type I

BGC0001123 - Region 1 - NRPS

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Location: 1 - 57,817 nt. (total: 57,817 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 57,818
Label		BGC0001123

Tailoring functions

Oxidoreductases: oxidoreductase oxygenase reductase

AO090001000028: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

AO090001000035: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

AO090001000037: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

AO090001000038: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

AO090001000041: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

AO090001000045: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: aminotransferase halogenase methyltransferase sulfotransferase

AO090001000024: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

AO090001000033: aminotransferase

smcogs: SMCOG1019: aminotransferase

AO090001000039: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

AO090001000040: glutathione S-transferase

smcogs: SMCOG1193: glutathione S-transferase

AO090001000046: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Ligases: ligase

AO090001000043: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001123.5	0.93	NRPS	aspirochlorine	Aspergillus oryzae RIB40
BGC0002135.2	0.65	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001240.4	0.61	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002075.3	0.59	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002164.2	0.58	NRPS	peramine	Epichloe festucae
BGC0001268.4	0.57	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0000292.4	0.49	NRPS	acetylaranotin	Aspergillus terreus NIH2624
BGC0001873.3	0.48	NRPS	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0000669.3	0.48	terpene	marneral	Arabidopsis thaliana
BGC0002226.3	0.47	NRPS	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001123.5	0.99	NRPS	aspirochlorine	Aspergillus oryzae RIB40
BGC0002608.2	0.80	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002341.2	0.76	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002135.2	0.65	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001240.4	0.61	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002075.3	0.59	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002164.2	0.58	NRPS	peramine	Epichloe festucae
BGC0001268.4	0.57	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001995.3	0.54	terpene	heptelidic acid	Aspergillus oryzae RIB40
BGC0002721.2	0.52	saccharide	α-hydroxynitrile glucoside, β-hydroxynitrile glucoside, γ-hydroxynitrile glucoside	Hordeum vulgare subsp. vulgare

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 12890 - 57817:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Phe)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AO090001000043: Phe

Search NORINE for peptide: strict or relaxed

AMP-binding (613..997): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DGHIYVMCGK
Nearest Stachelhaus code(s):: Phe DGHIYVMCGK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor