BGC0001141 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001141 (Penicillium brefeldianum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	37,663	High	4-epi-15-epi-brefeldin A	PKS:Iterative type I

BGC0001141 - Region 1 - T1PKS

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Location: 1 - 37,663 nt. (total: 37,663 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 37,664
Label		BGC0001141

Tailoring functions

Oxidoreductases: oxygenase

AIA58895.1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

AIA58896.1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

AIA58897.1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

AIA58898.1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Ligases: synthase

AIA58899.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001141.4	1.00	PKS	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0002191.2	0.64	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.62	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.60	PKS	FR901512	fungal sp. No.14919
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001141.4	1.00	PKS	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0002191.2	0.64	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.62	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.60	PKS	FR901512	fungal sp. No.14919
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 37663:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AIA58899.1: pk

PKS_AT (559..872): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 62.5%; 2-Methylbutyryl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 77.6
Methoxymalonyl-CoA: 68.7
Malonyl-CoA: 66.6
Ethylmalonyl-CoA: 44.9
Propionyl-CoA: 41.3
trans-1,2-CPDA: 38.2
Isobutyryl-CoA: 36.8
2-Methylbutyryl-CoA: 34.1
fatty_acid: 31.1
CHC-CoA: 22.1
Benzoyl-CoA: 14.5
3-Methylbutyryl-CoA: 14.4
Acetyl-CoA: 9.7
inactive: 0.0

Link to PARAS substrate predictor