BGC0001147: disgocidine biosynthetic gene cluster from Streptomyces netropsis
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Location: 1 - 28,600 nt. (total: 28,600 nt).
This entry is originally from NCBI GenBank KJ634466.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001147
Short description disgocidine biosynthetic gene cluster from Streptomyces netropsis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: partial
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Contig lacks AIS24865.1, AIS24866.1, AIS24867.1 as part of the NRPS"
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KJ634466.1
via Knock-out studies, Heterologous expression
Compounds
  • disgocidine
  • distamycin
  • congocidine
Species Streptomyces netropsis [taxonomy]
References
Chemical products information
disgocidine Evidence:
(no structure information available)
Chemical database entries
ChemSpider
distamycin Evidence:
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C22H27N9O4
Chemical database entries
PubCHEM
ChemSpider
congocidine Evidence:
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C18H26N10O3
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AIS24844.1
  • dst22
 99 - 1670 (-) dst22
  • Scaffold biosynthesis
  • Knock-out
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  • AIS24845.1
  • dst21
 1654 - 3558 (-) dst21
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    • AIS24846.1
    • dst20
    		 3558 - 5408 (-) dst20
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      • AIS24847.1
      • dst1
      		 5983 - 6657 (+) dst1
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        • AIS24848.1
        • dst2
        		 6990 - 8387 (+) dst2
        • Scaffold biosynthesis
        • Knock-out
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        • AIS24849.1
        • dst4
        		 8737 - 9282 (+) dst4
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          • AIS24850.1
          • dst5
          		 9279 - 10196 (+) dst5
          • Precursor biosynthesis
          • Knock-out
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          • AIS24851.1
          • dst6
          		 10193 - 10990 (+) dst6
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            • AIS24852.1
            • dst7
            		 11043 - 12176 (+) dst7
            • Precursor biosynthesis
            • Knock-out
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            • AIS24853.1
            • dst8
            		 12227 - 13531 (+) dst8
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              • AIS24854.1
              • dst9
              		 13524 - 14504 (+) dst9
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                • AIS24855.1
                • dst10
                		 14510 - 15583 (+) dst10
                • Precursor biosynthesis
                • Knock-out
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                • AIS24856.1
                • dst11
                		 15589 - 16344 (+) dst11
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                  • AIS24857.1
                  • dst12
                  		 16341 - 17492 (+) dst12
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                    • AIS24858.1
                    • dst13
                    		 17474 - 19390 (+) dst13
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                      • AIS24859.1
                      • dst15
                      		 19442 - 20215 (+) dst15
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                        • AIS24860.1
                        • dst16
                        		 20219 - 21628 (+) dst16
                        • Scaffold biosynthesis
                        • Knock-out
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                        • AIS24861.1
                        • dst17
                        		 21625 - 22671 (+) dst17
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                          • AIS24862.1
                          • dst18
                          		 22668 - 25859 (+) dst18
                          • Scaffold biosynthesis
                          • Knock-out
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                          • AIS24863.1
                          		 25936 - 27363 (-) Dst3
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                            • AIS24864.1
                            • dst19
                            		 27747 - 28109 (+) dst19
                            • Scaffold biosynthesis
                            • Knock-out
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                            Biosynthesis information

                            Biosynthetic modules

                            Name
                            Unk01
                            Type
                            nrps-type1
                            Genes
                            dst22
                            Substrates
                            4-acetamidopyrrole-2-carboxylic acid (evidence: )
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk04
                            Type
                            nrps-type1
                            Genes
                            dst18
                            Substrates
                            glycocyamine (evidence: )
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation
                            Annotation changelog

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Updated NRP substrate specificities
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            Detailed domain annotation
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