Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001147.1:
Cluster 1NRP128600
The following clusters are from record BGC0001147.2:
Cluster 2NRP17500

BGC0001147, distamycin biosynthetic gene cluster from Streptomyces netropsis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: disgocidine
ChemSpider ID: 133391
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
NRP
Other (linear)
Thioesterase type:
None
Release / cyclization type:
None

Nonribosomal peptide synthetases:
dst22 (AIS24844.1)
Module x
A specificity: 4-acetamidopyrrole-2-carboxylate
Evidence for specificity: Other
C domain subtype: N/A
dst2 (AIS24848.1)
Module x
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Other
dst16 (AIS24860.1)
Module x
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: LCL
dst18 (AIS24862.1)
Module x
A specificity: glycocyamine
Evidence for specificity: Other
C domain subtype: LCL
dst19 (AIS24864.1)
Module x
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: N/A
dst23 (AIS24865.1)
Module x
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: N/A
dst24 (AIS24866.1)
Module x
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: LCL
dst25 (AIS24867.1)
Module x
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Other

Gene cluster description

distamycin (BGC0001147). Gene Cluster 1. Biosynthetic class = NRP. GenBank KJ634466, positions 99-28109. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Sylvie Lautru (Centre National de la Recherche Scientifique)

Literature references

1. Vingadassalon A et al. (2015) Natural combinatorial biosynthesis involving two clusters for the synthesis of three pyrrolamides in Streptomyces netropsis. ACS Chem Biol 10(2):601-10. doi: 10.1021/cb500652n. Epub 2014 Dec 4.

BGC0001147, distamycin biosynthetic gene cluster from Streptomyces netropsis. Locus 2. Full MIBiG entry.

Chemical compounds

Compound: disgocidine
ChemSpider ID: 133391
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
NRP
Other (linear)
Thioesterase type:
None
Release / cyclization type:
None

Nonribosomal peptide synthetases:
dst22 (AIS24844.1)
Module x
A specificity: 4-acetamidopyrrole-2-carboxylate
Evidence for specificity: Other
C domain subtype: N/A
dst2 (AIS24848.1)
Module x
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Other
dst16 (AIS24860.1)
Module x
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: LCL
dst18 (AIS24862.1)
Module x
A specificity: glycocyamine
Evidence for specificity: Other
C domain subtype: LCL
dst19 (AIS24864.1)
Module x
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: N/A
dst23 (AIS24865.1)
Module x
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: N/A
dst24 (AIS24866.1)
Module x
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: LCL
dst25 (AIS24867.1)
Module x
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Other

Gene cluster description

distamycin (BGC0001147). Gene Cluster 2. Biosynthetic class = NRP. GenBank KJ634467, positions 701-7370. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Sylvie Lautru (Centre National de la Recherche Scientifique)

Literature references

1. Vingadassalon A et al. (2015) Natural combinatorial biosynthesis involving two clusters for the synthesis of three pyrrolamides in Streptomyces netropsis. ACS Chem Biol 10(2):601-10. doi: 10.1021/cb500652n. Epub 2014 Dec 4.