BGC0001149: brabantamide A biosynthetic gene cluster from Pseudomonas sp. SHC52
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Location: 196,768 - 209,553 nt. (total: 12,786 nt).
This entry is originally from NCBI GenBank CBLV010000330.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001149
Short description brabantamide A biosynthetic gene cluster from Pseudomonas sp. SHC52
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "The glycosyltransferase CDF96613.1 attaches D-rhamnose, which is synthesised by BN844_4691, BN844_4692, BN844_4693 in contig CBLV010000092.1"
Biosynthetic class(es)
  • NRPS (Type I)
  • saccharide (hybrid/tailoring)
Loci
CBLV010000330.1
196768 - 209553
via Knock-out studies
Compounds
  • brabantamide A
Species Pseudomonas sp. SHC52 [taxonomy]
References
Chemical products information
brabantamide A Evidence:
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C28H46N2O9
Chemical database entries
ChemSpider
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BN844_0705
  • CDF96613.1
 196768 - 198081 (+) RhlB, TDP-rhamnosyltransferase 1
  • Tailoring
  • Other in vivo study
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  • BN844_0706
  • CDF96614.1
 198177 - 205442 (+) NRPS
  • Scaffold biosynthesis
  • Knock-out
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  • BN844_0707
  • CDF96615.1
 205557 - 206720 (+) FAD-dependent Baeyer—Villiger monooxygenase
  • Tailoring
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  • BN844_0708
  • CDF96616.1
 207217 - 208044 (+) LuxR-type transcriptional regulator
  • Regulation
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  • BN844_0709
  • CDF96617.1
 208129 - 209553 (+) RND efflux system
  • Transport
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Biosynthesis information

Biosynthetic modules

Name
1
Type
nrps-type1
Genes
BN844_0706
Substrates
serine (evidence: Activity assay)
Integrated Monomers
Domains
condensation (Starter), adenylation
Name
2
Type
nrps-type1
Genes
BN844_0706
Substrates
proline (evidence: Sequence-based prediction)
Integrated Monomers
Domains
condensation (DCL), adenylation
Annotation changelog

Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Add new compound structure (SMILES) for brabantamide A
  • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Linked new PubChem id for brabantamide A (pubchem:129821380)
  • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Corrected NRP module activity
  • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Removed direct reference to D-rhamnose precursor supply genes that are outside of the cluster, on another contig
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Changed amino acid substrates to lower case
  • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted
  • (ID: KRKW7VUNYGF36O3Z7FAQ6YXG)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
Detailed domain annotation
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