Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001149.1:
Cluster 1NRP / Saccharide112786

BGC0001149, brabantamide biosynthetic gene cluster from Pseudomonas sp. SHC52. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: brabantamide A
ChemSpider ID: 8274723
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
NRP / Saccharide
Nonribosomal peptide subclass:
Other lipopeptide (cyclic)
3-OH tetradecanoic acid
Thioesterase type:
Unknown
Release / cyclization type:
Other

Nonribosomal peptide synthetases:
BraB (CDF96614.1)
Module 1
A specificity: Serine
Evidence for specificity: Activity assay
C domain subtype: Starter
Module 2
A specificity: Proline
Evidence for specificity: Sequence-based prediction
C domain subtype: DCL
Saccharide subclass:
hybrid/tailoring
Glycosyltransferases:
CDF96613.1:
Specificity: D-rhamnose
Evidence for specificity: Structure-based inference
Sugar biosynthesis subcluster: BN844_4693, BN844_4692, BN844_4691

Gene cluster description

brabantamide (BGC0001149). Gene Cluster 1. Biosynthetic class = NRP/Saccharide. GenBank CBLV010000330, positions 196768-209553. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Harald Gross (University of Tuebingen)

Literature references

1. Schmidt Y et al. (2014) Biosynthetic origin of the antibiotic cyclocarbamate brabantamide A (SB-253514) in plant-associated Pseudomonas. Chembiochem 15(2):259-66. doi: 10.1002/cbic.201300527.