BGC0001149: brabantamide A biosynthetic gene cluster from Pseudomonas sp. SHC52
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Location: 196,768 - 209,553 nt. (total: 12,786 nt).
This entry is originally from NCBI GenBank CBLV010000330.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001149
Short description brabantamide A biosynthetic gene cluster from Pseudomonas sp. SHC52
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "The glycosyltransferase CDF96613.1 attaches D-rhamnose, which is synthesised by BN844_4691, BN844_4692, BN844_4693 in contig CBLV010000092.1"
Biosynthetic class(es)
  • NRP (Other lipopeptide)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: CBLV010000330.1
Compounds
  • brabantamide A
Species Pseudomonas sp. SHC52 [taxonomy]
References
Chemical products information
brabantamide A [synonyms: sb-253514]
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C28H46N2O9
Chemical database entries
ChemSpider
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BN844_0705
  • CDF96613.1
 196768 - 198081 (+) RhlB, TDP-rhamnosyltransferase 1
  • Tailoring (Glycosylation)
Other in vivo study
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  • BN844_0706
  • CDF96614.1
 198177 - 205442 (+) NRPS
  • Scaffold biosynthesis
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  • BN844_0707
  • CDF96615.1
 205557 - 206720 (+) FAD-dependent Baeyer—Villiger monooxygenase
  • Tailoring (Oxidation)
Sequence-based prediction
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  • BN844_0708
  • CDF96616.1
 207217 - 208044 (+) LuxR-type transcriptional regulator
  • Regulation
Sequence-based prediction
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  • BN844_0709
  • CDF96617.1
 208129 - 209553 (+) RND efflux system
  • Transport
Sequence-based prediction
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NRP-specific information
Subclass Other lipopeptide
Cyclic? yes
Lipid moiety 3-OH tetradecanoic acid
Thioesterase genes
  • BN844_0706 (Unknown)
NRP-synthases
Gene Modules
BN844_0706
Module 1
Specificity: serine
Evidence for specificity:
  • Activity assay
Condensation domain type: Starter
Module 2
Specificity: proline
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Saccharide-specific information
Subclass hybrid/tailoring
Glycosyltransferases
BN844_0705
Specificity: D-rhamnose
Evidence:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: KRKW7VUNYGF36O3Z7FAQ6YXG, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Add new compound structure (SMILES) for brabantamide A
  • Linked new PubChem id for brabantamide A (pubchem:129821380)
  • Corrected NRP module activity
  • Removed direct reference to D-rhamnose precursor supply genes that are outside of the cluster, on another contig
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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