BGC0001157: bottromycin A2 biosynthetic gene cluster from Streptomyces scabiei 87.22
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Location: 6,304,534 - 6,321,700 nt. (total: 17,167 nt).
This entry is originally from NCBI GenBank FN554889.1.

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core biosynthetic genes
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001157
Short description bottromycin A2 biosynthetic gene cluster from Streptomyces scabiei 87.22
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "The reference reporting the BGC (doi:10.1039/C2SC21190D) refers to the producer strain as 'Streptomyces scabies 87.22'."
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
FN554889.1
6304534 - 6321700
via Knock-out studies
Compounds
  • bottromycin A2
Species Streptomyces scabiei 87.22 [taxonomy]
References
Chemical products information
bottromycin A2 Evidence:
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C42H62N8O7S1
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SCAB_56591
  • CBG72685.1
 6304534 - 6305976 (-) putative cytosolic aminopeptidase
  • Tailoring
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  • SCAB_56601
  • CBG72686.1
 6305981 - 6306553 (-) hypothetical protein
  • Regulation
  • Knock-out
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  • SCAB_56611
  • CBG72687.1
 6306673 - 6308631 (-) Radical SAM methyltransferase
  • Tailoring
  • Knock-out
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  • SCAB_56621
  • CBG72688.1
 6308639 - 6309775 (-) P450
  • Tailoring
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  • SCAB_56631
  • CBG72689.1
 6309855 - 6311276 (-) Putative hydrolase
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    • SCAB_56641
    • CBG72690.1
    		 6311273 - 6312088 (-) Putative hydrolase
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      • SCAB_56651
      • CBG72691.1
      		 6312123 - 6314138 (-) Radical SAM methyltransferase
      • Tailoring
      • Knock-out
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      • SCAB_56661
      • CBG72692.1
      		 6314135 - 6315574 (-) YcaO domain protein
      • Tailoring
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      • SCAB_56671
      • CBG72693.1
      		 6315426 - 6316682 (-) YcaO domain protein
      • Tailoring
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      • SCAB_56681
      • CBG72694.1
      		 6316746 - 6316880 (-) Precursor peptide
      • Scaffold biosynthesis
      • Knock-out
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      • SCAB_56691
      • CBG72695.1
      		 6317014 - 6318951 (-) Radical SAM methyltransferase
      • Tailoring
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      • SCAB_56701
      • CBG72696.1
      		 6319368 - 6320207 (+) Methyltransferase
      • Tailoring
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      • SCAB_56711
      • CBG72697.1
      		 6320390 - 6321700 (+) Major facilitator superfamily protein
      • Transport
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      Biosynthesis information
      Annotation changelog

      Entry version: next

      Date
      Changes
      Submitters
      Reviewers
      2023-11-17
      Specified chemical target, added RiPP annotation. Added a review paper (doi:10.1039/D0NP00097C) which unifies the bottromycin gene designation.
      • (ID: C62OJVVH7XOTOTFZSJT727YU)
      • (ID: DKBFG3K6XTYSVEQEQVCFZBWY)

      Entry version: 4

      Date
      Changes
      Submitters
      Reviewers
      2022-10-07
      Update chemical activity to schema version 2.11
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 3

      Date
      Changes
      Submitters
      Reviewers
      2022-09-15
      Updated bioactivity data
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 2

      Date
      Changes
      Submitters
      Reviewers
      2019-10-16
      Migrated from v1.4
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 1

      Date
      Changes
      Submitters
      Reviewers
      2015-06-12
      Submitted
      • (ID: YDLZYFWUWQQQNGTRZENZCBP5)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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