Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001159.1:
Cluster 1NRP / Polyketide143083

BGC0001159, marinopyrrole biosynthetic gene cluster from Streptomyces sp. CNQ-418. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: marinopyrrole A
SMILES string: Copy to clipboard
Molecular formula: C22H12Cl4N2O4
Exact molecular mass: 507.9551 Da (None)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
None
Release / cyclization type:
Other

Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Other
Thioesterase type:
Type I & II
Release / cyclization type:
Other

Modular polyketide synthases:
mpy7 (AFP87524.1)
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None
Module 2
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None

mpy6 (AFP87523.1)
Module 3
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

Gene cluster description

marinopyrrole (BGC0001159). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank JX157625, positions 1-43083. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Bradley S Moore (University of California San Diego)

Literature references

1. Yamanaka K et al. (2012) Flavoenzyme-catalyzed atropo-selective N,C-bipyrrole homocoupling in marinopyrrole biosynthesis. J Am Chem Soc 134(30):12434-7. doi: 10.1021/ja305670f. Epub 2012 Jul