BGC0001159 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001159 (Streptomyces sp. CNQ-418)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	43,083	pyrrolomycin A / pyrrolomycin B / pyrrolomycin C / pyrrolomycin D	Polyketide	37%

BGC0001159 - Region 1 - T1PKS

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Location: 1 - 43,083 nt. (total: 43,083 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 43,084
Label		BGC0001159

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001159.1	0.83	NRP, Polyketide	marinopyrrole A, marinopyrrole E, marinopyrrole D, marinopyrrole C, marinopyrrole B	Streptomyces sp. CNQ-418
BGC0001778.1	0.30	Other	showdomycin	Streptomyces showdoensis
BGC0000041.1	0.30	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000924.1	0.29	Other	pyrrolnitrin	Pseudomonas chlororaphis
BGC0000003.1	0.28	Polyketide	AF-toxin	Alternaria alternata
BGC0000046.1	0.27	Polyketide	depudecin	Alternaria brassicicola
BGC0001280.1	0.26	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.26	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001399.1	0.25	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001337.1	0.25	Alkaloid	lazarimide A, lazarimide B, lazarimide C	uncultured bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001159.1	0.94	NRP, Polyketide	marinopyrrole A, marinopyrrole E, marinopyrrole D, marinopyrrole C, marinopyrrole B	Streptomyces sp. CNQ-418
BGC0001778.1	0.64	Other	showdomycin	Streptomyces showdoensis
BGC0000041.1	0.63	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000924.1	0.63	Other	pyrrolnitrin	Pseudomonas chlororaphis
BGC0000003.1	0.62	Polyketide	AF-toxin	Alternaria alternata
BGC0000046.1	0.61	Polyketide	depudecin	Alternaria brassicicola
BGC0001280.1	0.60	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.60	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001399.1	0.58	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001337.1	0.58	Alkaloid	lazarimide A, lazarimide B, lazarimide C	uncultured bacterium

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 43083:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (ohmal)
Non-colinear ordering:: mpy7 + mpy6

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

mpy2

Search NORINE for peptide: strict or relaxed

AMP-binding (8..445): X

NRPSPredictor2: gly, ala, val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DlFyVAwVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 70% (weak)

mpy6

PKS_AT (574..868): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 182.3
inactive: 91.8
Methoxymalonyl-CoA: 78.0
Methylmalonyl-CoA: 70.6
Isobutyryl-CoA: 52.4
Propionyl-CoA: 48.9
Ethylmalonyl-CoA: 32.3
trans-1,2-CPDA: 17.2
Acetyl-CoA: 16.9
Benzoyl-CoA: 14.0
fatty_acid: 13.8
CHC-CoA: 13.1
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -2.4

mpy7

PKS_AT (554..850): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Methylmalonyl-CoA: 58.3%; Propionyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 94.6
Malonyl-CoA: 91.3
Methoxymalonyl-CoA: 78.4
Propionyl-CoA: 54.2
inactive: 43.1
Ethylmalonyl-CoA: 39.4
trans-1,2-CPDA: 29.4
Isobutyryl-CoA: 24.2
2-Methylbutyryl-CoA: 24.0
Benzoyl-CoA: 21.9
Acetyl-CoA: 18.7
CHC-CoA: 16.1
fatty_acid: 12.6
3-Methylbutyryl-CoA: -0.1