Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001160.1:
Cluster 1Polyketide18163

BGC0001160, nonadecene biosynthetic gene cluster from Synechococcus sp. PCC. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: 1-nonadecene
PubChem ID: 29075
SMILES string: Copy to clipboard
Molecular formula: C19H38
Average molecular mass: 266.513 Da
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Malonyl-CoA
Thioesterase type:
Type I
Release / cyclization type:
Other

Modular polyketide synthases:
6056266 (ACA99172)
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: Other

Gene cluster description

nonadecene (BGC0001160). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank CP000951, positions 1205897-1214059. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Heterologous expression, Sequence-based prediction
MIxS-compliance:Unknown
Comments:The thioester release mechanism of this pathway involves a release via hydrolysis and decarboxylation which was not an option for this submission.
Contact for this cluster:R. Cameron Coates (DOE Joint Genome Institute)

Literature references

1. Coates RC et al. (2014 TI) Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways. PLoS One 9(1):e85140. doi: 10.1371/journal.pone.0085140. eCollection
2. Mendez-Perez D et al. (2011) Modular synthase-encoding gene involved in alpha-olefin biosynthesis in Synechococcus sp. strain PCC 7002. Appl Environ Microbiol 77(12):4264-7. doi: 10.1128/AEM.00467-11. Epub
3. Mendez-Perez D et al. (2014) A desaturase gene involved in the formation of 1,14-nonadecadiene in Synechococcus sp. strain PCC 7002. Appl Environ Microbiol 80(19):6073-9. doi: 10.1128/AEM.01615-14. Epub
4. McCarthy JG et al. (2012) Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. ACS Chem Biol 7(12):1994-2003. doi: 10.1021/cb300385m. Epub 2012 Sep