Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001168.1:
Cluster 1NRP14582

BGC0001168, livipeptin biosynthetic gene cluster from Streptomyces lividans. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Livipeptin
Exact molecular mass: 347.16 Da (M+)
Molecular activity: Inhibitor
Molecular target: Trypsin

Class-specific details

Biosynthetic class(es):
NRP
Other (linear)
Thioesterase type:
None
Release / cyclization type:
Reductive release

Nonribosomal peptide synthetases:
SLI_0883 (509516289)
Module 1
A specificity: Arginine
Evidence for specificity: Sequence-based prediction
C domain subtype: N/A

Gene cluster description

livipeptin (BGC0001168). Gene Cluster 1. Biosynthetic class = NRP. GenBank CM001889, positions 891947-896528. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

General MIBiG information on this cluster

Complete gene cluster sequence?unknown
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression, Gene expression correlated with compound production, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Pablo Cruz Morales (National Laboratory of genomics for biodiversity-CINVESTAV)

Literature references

1. Cruz-Morales P et al. (2013 TI) The genome sequence of Streptomyces lividans 66 reveals a novel tRNA-dependent peptide biosynthetic system within a metal-related genomic island. Genome Biol Evol 5(6):1165-75. doi: 10.1093/gbe/evt082.