BGC0001169: piericidin A1 biosynthetic gene cluster from Streptomyces sp. SCSIO 03032
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 49,160 nt. (total: 49,160 nt).
This entry is originally from NCBI GenBank KF874660.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001169
Short description piericidin A1 biosynthetic gene cluster from Streptomyces sp. SCSIO 03032
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
KF874660.1
via Knock-out studies, Enzymatic assays
Compounds
  • piericidin A1
Species Streptomyces sp. SCSIO 03032 [taxonomy]
References
Chemical products information
piericidin A1 Evidence:
Copy SMILES
C25H37N1O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHE80990.1
 1 - 801 (-) PieR
    copy AA seq
    copy Nt seq
    • AHE80991.1
    		 1190 - 8497 (+) PieA1
      copy AA seq
      copy Nt seq
      • AHE80992.1
      		 8530 - 18633 (+) PieA2
        copy AA seq
        copy Nt seq
        • AHE80993.1
        		 18700 - 23964 (+) PieA3
          copy AA seq
          copy Nt seq
          • AHE80994.1
          		 23977 - 30507 (+) PieA4
            copy AA seq
            copy Nt seq
            • AHE80995.1
            		 30534 - 36179 (+) PieA5
              copy AA seq
              copy Nt seq
              • AHE80996.1
              		 36194 - 43381 (+) PieA6
                copy AA seq
                copy Nt seq
                • AHE80997.1
                		 43378 - 44067 (+) PieB1
                  copy AA seq
                  copy Nt seq
                  • AHE80998.1
                  		 44183 - 44725 (+) PieC
                    copy AA seq
                    copy Nt seq
                    • AHE80999.1
                    		 44727 - 46568 (+) PieD
                      copy AA seq
                      copy Nt seq
                      • AHE81000.1
                      		 46582 - 47367 (+) PieB2
                        copy AA seq
                        copy Nt seq
                        • AHE81001.1
                        		 47364 - 49160 (+) PieE
                          copy AA seq
                          copy Nt seq
                          Biosynthesis information

                          Biosynthetic modules

                          Name
                          0
                          Type
                          pks-modular
                          Genes
                          AHE80991.1
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                          Name
                          1
                          Type
                          pks-modular
                          Genes
                          AHE80991.1
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                          Name
                          2
                          Type
                          pks-modular
                          Genes
                          AHE80992.1
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                          Name
                          3
                          Type
                          pks-modular
                          Genes
                          AHE80992.1
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                          Name
                          4
                          Type
                          pks-modular
                          Genes
                          AHE80993.1
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                          Name
                          5
                          Type
                          pks-modular
                          Genes
                          AHE80994.1
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                          Name
                          6
                          Type
                          pks-modular
                          Genes
                          AHE80995.1
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                          Name
                          7
                          Type
                          pks-modular
                          Genes
                          AHE80996.1
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                          Name
                          8
                          Type
                          pks-modular
                          Genes
                          AHE80996.1
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                          Annotation changelog

                          Entry version: 4

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-10-07
                          Update chemical activity to schema version 2.11
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 3

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-09-15
                          Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Sorted modules by module number
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Corrected gene identifiers
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Updated bioactivity data
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 2

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2019-10-16
                          Migrated from v1.4
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 1

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2015-06-12
                          Submitted
                          • (ID: YU43TGF6RSKW2WJOQIFYBQO4)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          Detailed domain annotation
                          Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                          A domain glossary is available here, and an explanation of the visualisation is available here.
                          Selected features only
                          Show module domains
                          Similar known gene clusters from MIBiG 4.0
                          Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                          Click on reference genes to show details of similarities to genes within the current region.
                          Click on an accession to open that entry in the MiBIG database.