Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001185.1:
Cluster 1NRP111721

BGC0001185, bacillibactin biosynthetic gene cluster from Bacillus amyloliquefaciens. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: bacillibactin
PubChem ID: 125349
SMILES string: Copy to clipboard
Molecular formula: C39H42N6O18
Average molecular mass: 882.789 Da
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
NRP
NRP siderophore (cyclic)
Thioesterase type:
None
Release / cyclization type:
None

Nonribosomal peptide synthetases:
dhbE (ABS75234.1)
Module 0
A specificity: dhb
Evidence for specificity: Sequence-based prediction
C domain subtype: N/A
dhbF (ABS75232.1)
Module 1
A specificity: Glycine
Evidence for specificity: Sequence-based prediction
C domain subtype: Starter
Module 2
A specificity: Threonine
Evidence for specificity: Sequence-based prediction
C domain subtype: LCL

Gene cluster description

bacillibactin (BGC0001185). Gene Cluster 1. Biosynthetic class = NRP. GenBank CP000560, positions 3021250-3032970. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Comments:Deletion of the complete FZB42 bacillibactin gene cluster covering genomic region 3021250-3032970 revealed that ability to produce bacillibactin has been lost completely. Construction of mutants devoid in bacillibactin production RS01 (delta bac) and RS06 (delta sfp, delta bac) has been described in PMID 19061923
Contact for this cluster:Rainer Borriss (Humboldt University)

Literature references

1. Chen XH et al. (2009 TI) More than anticipated - production of antibiotics and other secondary metabolites by Bacillus amyloliquefaciens FZB42. J Mol Microbiol Biotechnol 16(1-2):14-24. doi: 10.1159/000142891. Epub 2008