BGC0001185: bacillibactin biosynthetic gene cluster from Bacillus velezensis FZB42
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Location: 3,021,250 - 3,032,970 nt. (total: 11,721 nt).
This entry is originally from NCBI GenBank CP000560.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001185
Short description bacillibactin biosynthetic gene cluster from Bacillus velezensis FZB42
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Deletion of the complete FZB42 bacillibactin gene cluster covering genomic region 3021250-3032970 revealed that ability to produce bacillibactin has been lost completely. Construction of mutants devoid in bacillibactin production RS01 (delta bac) and RS06 (delta sfp, delta bac) has been described in PMID 19061923 "
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP000560.1
3021250 - 3032970
via Knock-out studies
Compounds
  • bacillibactin
Species Bacillus velezensis FZB42 [taxonomy]
References
Chemical products information
bacillibactin Evidence:
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C39H42N6O18
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • RBAM_029010
  • ABS75232.1
  • dhbF
 3021250 - 3028377 (-) DhbF
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    • RBAM_029020
    • ABS75233.1
    • dhbB
    		 3028392 - 3029318 (-) DhbB
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      • RBAM_029030
      • ABS75234.1
      • dhbE
      		 3029336 - 3030961 (-) DhbE
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        • RBAM_029040
        • ABS75235.1
        • dhbC
        		 3030980 - 3032176 (-) DhbC
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          • RBAM_029050
          • ABS75236.1
          • dhbA
          		 3032200 - 3032970 (-) DhbA
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            Biosynthesis information

            Biosynthetic modules

            Name
            0
            Type
            nrps-type1
            Genes
            dhbE
            Substrates
            2,3-dihydroxybenzoic acid (evidence: Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Name
            1
            Type
            nrps-type1
            Genes
            dhbF
            Substrates
            glycine (evidence: Sequence-based prediction)
            Integrated Monomers
            Domains
            condensation (Starter), adenylation
            Name
            2
            Type
            nrps-type1
            Genes
            dhbF
            Substrates
            threonine (evidence: Sequence-based prediction)
            Integrated Monomers
            Domains
            condensation (LCL), adenylation
            Annotation changelog

            Entry version: 4

            Date
            Changes
            Submitters
            Reviewers
            2022-10-07
            Update chemical activity to schema version 2.11
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 3

            Date
            Changes
            Submitters
            Reviewers
            2022-09-15
            Corrected NRP module activity
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Updated bioactivity data
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Updated NRP substrate specificities
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 2

            Date
            Changes
            Submitters
            Reviewers
            2019-10-16
            Migrated from v1.4
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 1

            Date
            Changes
            Submitters
            Reviewers
            2015-08-17
            Submitted
            • (ID: FICEQDRJCNKWHHGNCRVDDP5D)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            Detailed domain annotation
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