BGC0001185: bacillibactin biosynthetic gene cluster from Bacillus velezensis FZB42
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 3,021,250 - 3,032,970 nt. (total: 11,721 nt).
This entry is originally from NCBI GenBank CP000560.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001185
Short description bacillibactin biosynthetic gene cluster from Bacillus velezensis FZB42
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "Deletion of the complete FZB42 bacillibactin gene cluster covering genomic region 3021250-3032970 revealed that ability to produce bacillibactin has been lost completely. Construction of mutants devoid in bacillibactin production RS01 (delta bac) and RS06 (delta sfp, delta bac) has been described in PMID 19061923 "
Biosynthetic class(es)
  • NRP (NRP siderophore)
Loci NCBI GenBank: CP000560.1
Compounds
  • bacillibactin
Species Bacillus velezensis FZB42 [taxonomy]
References
Chemical products information
bacillibactin
Copy SMILES
C39H42N6O18
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • RBAM_029010
  • ABS75232.1
  • dhbF
3021250 - 3028377 (-) DhbF
copy AA seq
copy Nt seq
  • RBAM_029020
  • ABS75233.1
  • dhbB
3028392 - 3029318 (-) DhbB
copy AA seq
copy Nt seq
  • RBAM_029030
  • ABS75234.1
  • dhbE
3029336 - 3030961 (-) DhbE
copy AA seq
copy Nt seq
  • RBAM_029040
  • ABS75235.1
  • dhbC
3030980 - 3032176 (-) DhbC
copy AA seq
copy Nt seq
  • RBAM_029050
  • ABS75236.1
  • dhbA
3032200 - 3032970 (-) DhbA
copy AA seq
copy Nt seq
NRP-specific information
Subclass NRP siderophore
Cyclic? yes
NRP-synthases
Gene Modules
dhbE
Module 0
Specificity: 2,3-dihydroxybenzoic acid
Evidence for specificity:
  • Sequence-based prediction
dhbF
Module 1
Specificity: glycine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Starter
Module 2
Specificity: threonine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.1
  • Hidden contributor (ID: FICEQDRJCNKWHHGNCRVDDP5D, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated bioactivity data
  • Updated NRP substrate specificities
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.