BGC0001185: bacillibactin biosynthetic gene cluster from Bacillus velezensis FZB42
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Location: 3,021,250 - 3,032,970 nt. (total: 11,721 nt).
This entry is originally from NCBI GenBank CP000560.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001185
Short description bacillibactin biosynthetic gene cluster from Bacillus velezensis FZB42
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "Deletion of the complete FZB42 bacillibactin gene cluster covering genomic region 3021250-3032970 revealed that ability to produce bacillibactin has been lost completely. Construction of mutants devoid in bacillibactin production RS01 (delta bac) and RS06 (delta sfp, delta bac) has been described in PMID 19061923 "
Biosynthetic class(es)
  • NRP (NRP siderophore)
Loci NCBI GenBank: CP000560.1
Compounds
  • bacillibactin
Species Bacillus velezensis FZB42 [taxonomy]
References
Chemical products information
bacillibactin
Copy SMILES
C39H42N6O18
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • RBAM_029010
  • ABS75232.1
  • dhbF
 3021250 - 3028377 (-) DhbF
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  • RBAM_029020
  • ABS75233.1
  • dhbB
 3028392 - 3029318 (-) DhbB
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  • RBAM_029030
  • ABS75234.1
  • dhbE
 3029336 - 3030961 (-) DhbE
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  • RBAM_029040
  • ABS75235.1
  • dhbC
 3030980 - 3032176 (-) DhbC
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  • RBAM_029050
  • ABS75236.1
  • dhbA
 3032200 - 3032970 (-) DhbA
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NRP-specific information
Subclass NRP siderophore
Cyclic? yes
NRP-synthases
Gene Modules
dhbE
Module 0
Specificity: 2,3-dihydroxybenzoic acid
Evidence for specificity:
  • Sequence-based prediction
dhbF
Module 1
Specificity: glycine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Starter
Module 2
Specificity: threonine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.1
  • Hidden contributor (ID: FICEQDRJCNKWHHGNCRVDDP5D, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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