BGC0001194: hitachimycin biosynthetic gene cluster from Streptomyces scabrisporus
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Location: 1 - 72,530 nt. (total: 72,530 nt).
This entry is originally from NCBI GenBank LC008143.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001194
Short description hitachimycin biosynthetic gene cluster from Streptomyces scabrisporus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
LC008143.1
via
Compounds
  • hitachimycin
Species Streptomyces scabrisporus [taxonomy]
References
Chemical products information
hitachimycin Evidence:
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C29H35N1O5
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAR73004.1
  • hitM1
 1 - 873 (-) putative short-chain dehydrogenase
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    • BAR73005.1
    • hitM2
    		 887 - 1753 (-) putative sugar phosphate isomerase/epimerase
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      • BAR73006.1
      • hitA
      		 2068 - 3621 (+) putative phenylalanine-2,3-aminomutase
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        • BAR73007.1
        • hitP1
        		 3820 - 15771 (-) putative PKS (ACP-KS-AT-DH-KR-ACP-KS-AT-DH-ER-KR-ACP)
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          • BAR73008.1
          • hitB
          		 15870 - 17471 (-) putative ATP-dependent b-aminoacyl-ACP synthetase
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            • BAR73009.1
            • hitC
            		 17677 - 18624 (+) putative ACP aminoacyltransferase
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              • BAR73010.1
              • hitD
              		 18632 - 18880 (-) putative ACP
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                • BAR73011.1
                • hitE
                		 18994 - 20544 (+) putative ATP-dependent aminoacyl-ACP synthetase
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                  • BAR73012.1
                  • hitR1
                  		 20590 - 21312 (-) putative TetR family transcriptional regulator
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                    • BAR73013.1
                    • hitM3
                    		 21953 - 23191 (+) putative cytochrome P450 monooxygenase
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                      • BAR73014.1
                      • hitM4
                      		 23349 - 24215 (-) putative 3-ketoacyl-ACP reductase
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                        • BAR73015.1
                        • hitR2
                        		 24410 - 24847 (-) putative cold-shock protein (regulator)
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                          • BAR73016.1
                          • hitT1
                          		 25115 - 26731 (-) putative MFS transporter
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                            • BAR73017.1
                            • hitP2
                            		 26901 - 36878 (-) putative PKS (KS-AT-KR-ACP-KS-AT-DH-KR-ACP)
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                              • BAR73018.1
                              • hitF
                              		 36944 - 37852 (-) putative amidohydrolase
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                                • BAR73019.1
                                • hitP3
                                		 37994 - 44008 (-) putative PKS (KS-AT-DH-KR-ACP-TE)
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                                  • BAR73020.1
                                  • hitP4
                                  		 44016 - 59576 (-) putative PKS (KS-AT-DH-KR-ACP-KS-AT-DH-KR-ACP-KS-AT-DH-KR-ACP)
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                                    • BAR73021.1
                                    • hitP5
                                    		 59610 - 64448 (-) putative PKS (KS-AT-KR-ACP)
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                                      • BAR73022.1
                                      • hitM5
                                      		 64495 - 65400 (-) putative sugar phosphate isomerase/epimerase
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                                        • BAR73023.1
                                        • hitM6
                                        		 65619 - 66272 (+) putative O-methyltransferase
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                                          • BAR73024.1
                                          • hitR3
                                          		 66353 - 69007 (-) putative LuxR-family transcriptional regulator
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                                            • BAR73025.1
                                            • hitR4
                                            		 69726 - 72530 (+) putative LuxR-family transcriptional regulator
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                                              Biosynthesis information
                                              Annotation changelog

                                              Entry version: 4

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-10-07
                                              Update chemical activity to schema version 2.11
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 3

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-09-15
                                              Updated bioactivity data
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 2

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2019-10-16
                                              Migrated from v1.4
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 1

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2015-08-17
                                              Submitted
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              Detailed domain annotation
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