BGC0001199 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001199 (Streptomyces sp. NBRC 109706)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	63,400	auroramycin	Polyketide	14%

BGC0001199 - Region 1 - T1PKS

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Location: 1 - 63,400 nt. (total: 63,400 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 63,401
Label		BGC0001199

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001199.1	0.83	Polyketide	akaeolide	Streptomyces sp. NBRC 109706
BGC0000041.1	0.34	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000068.1	0.32	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0000286.1	0.31	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0002031.1	0.31	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000160.1	0.31	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0001273.1	0.31	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000067.1	0.30	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001276.1	0.30	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.1	0.30	Polyketide	(-)-Mellein	Parastagonospora nodorum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001199.1	0.94	Polyketide	akaeolide	Streptomyces sp. NBRC 109706
BGC0000041.1	0.67	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000068.1	0.65	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0000286.1	0.65	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0002031.1	0.65	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000160.1	0.65	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0001273.1	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000067.1	0.64	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001276.1	0.64	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.1	0.63	Polyketide	(-)-Mellein	Parastagonospora nodorum

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 63400:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal - Me-redmal) + (ccmal - Me-ccmal) + (mal - pk) + (mal)
Non-colinear ordering:: ctg1_orf521 + ctg1_orf522 + ctg1_orf523 + ctg1_orf524

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_orf521

PKS_AT (548..841): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 168.5
inactive: 89.6
Methylmalonyl-CoA: 56.5
Methoxymalonyl-CoA: 49.1
Isobutyryl-CoA: 30.2
Ethylmalonyl-CoA: 26.6
Propionyl-CoA: 22.9
Benzoyl-CoA: 18.8
fatty_acid: 16.0
Acetyl-CoA: 15.0
trans-1,2-CPDA: 7.5
CHC-CoA: 5.1
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (1556..1855): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.7
Ethylmalonyl-CoA: 190.6
Methoxymalonyl-CoA: 162.9
trans-1,2-CPDA: 118.4
2-Methylbutyryl-CoA: 118.2
Propionyl-CoA: 93.4
Malonyl-CoA: 91.6
CHC-CoA: 90.2
Isobutyryl-CoA: 73.6
Benzoyl-CoA: 66.8
Acetyl-CoA: 54.9
fatty_acid: 41.0
3-Methylbutyryl-CoA: 36.4
inactive: 27.1

PKS_AT (3304..3603): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 206.6
Ethylmalonyl-CoA: 189.2
Methoxymalonyl-CoA: 166.6
trans-1,2-CPDA: 118.6
2-Methylbutyryl-CoA: 116.8
Malonyl-CoA: 98.3
Propionyl-CoA: 93.4
CHC-CoA: 87.7
Isobutyryl-CoA: 76.1
Benzoyl-CoA: 72.4
Acetyl-CoA: 50.6
fatty_acid: 41.0
3-Methylbutyryl-CoA: 37.9
inactive: 28.2

ctg1_orf522

PKS_AT (561..854): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 165.7
inactive: 87.3
Methylmalonyl-CoA: 53.9
Methoxymalonyl-CoA: 45.3
Benzoyl-CoA: 27.7
Isobutyryl-CoA: 26.0
Propionyl-CoA: 20.1
Ethylmalonyl-CoA: 19.4
Acetyl-CoA: 13.3
fatty_acid: 11.1
CHC-CoA: 7.9
trans-1,2-CPDA: 6.2
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2304..2603): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 206.6
Ethylmalonyl-CoA: 189.2
Methoxymalonyl-CoA: 166.6
trans-1,2-CPDA: 118.6
2-Methylbutyryl-CoA: 116.8
Malonyl-CoA: 98.3
Propionyl-CoA: 93.4
CHC-CoA: 87.7
Isobutyryl-CoA: 76.1
Benzoyl-CoA: 72.4
Acetyl-CoA: 50.6
fatty_acid: 41.0
3-Methylbutyryl-CoA: 37.9
inactive: 28.2

ctg1_orf523

PKS_AT (569..863): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 170.8
inactive: 79.2
Methylmalonyl-CoA: 48.7
Methoxymalonyl-CoA: 44.5
Isobutyryl-CoA: 26.3
Ethylmalonyl-CoA: 22.7
Benzoyl-CoA: 17.4
Propionyl-CoA: 17.3
Acetyl-CoA: 15.8
fatty_acid: 15.7
CHC-CoA: 11.9
trans-1,2-CPDA: 7.7
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (1597..1896): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 227.2
Methylmalonyl-CoA: 208.1
Methoxymalonyl-CoA: 174.7
2-Methylbutyryl-CoA: 167.9
trans-1,2-CPDA: 152.2
CHC-CoA: 122.0
Propionyl-CoA: 116.5
Malonyl-CoA: 102.4
Isobutyryl-CoA: 92.0
Benzoyl-CoA: 72.7
Acetyl-CoA: 59.3
3-Methylbutyryl-CoA: 42.0
inactive: 36.9
fatty_acid: 27.2

ctg1_orf524

PKS_AT (561..855): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 170.7
inactive: 80.8
Methylmalonyl-CoA: 49.4
Methoxymalonyl-CoA: 42.0
Isobutyryl-CoA: 30.0
Propionyl-CoA: 21.6
Ethylmalonyl-CoA: 20.0
Acetyl-CoA: 18.6
Benzoyl-CoA: 16.4
fatty_acid: 15.6
CHC-CoA: 13.5
trans-1,2-CPDA: 13.2
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0