BGC0001204 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001204 (Streptomyces versipellis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	115,042	High	versipelostatin	PKS

BGC0001204 - Region 1 - T1PKS

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Location: 1 - 115,042 nt. (total: 115,042 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 115,043
Label		BGC0001204

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

vstB3: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

vstD: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

vstK: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

vstL: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

vstP: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

Transferases: acylase glycosyltransferase transferase

vstA5: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

vstB7: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

vstH: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

vstI: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Hydrolases: esterase phosphatase

vstC1: FkbH like protein

smcogs: SMCOG1256: FkbH like protein

vstM: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: cyclase dehydratase

vstB1: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

vstB4: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

vstB8: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

vstJ: Diels-Alderase cyclase

extras: DA_cyclase: Diels-Alderase cyclase

Ligases: synthase

vstA1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

vstA2: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

vstA3: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

vstA4: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

vstC5: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

vstF: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001204.5	1.00	PKS	versipelostatin	Streptomyces versipellis
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.75	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000041.3	0.72	PKS	oronofacic acid	Pseudomonas syringae
BGC0000067.5	0.67	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001204.5	1.00	PKS	versipelostatin	Streptomyces versipellis
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.75	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000041.3	0.72	PKS	oronofacic acid	Pseudomonas syringae
BGC0000067.5	0.67	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 114678:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - pk - Me-ccmal - redmal - Me-redmal) + (Me-ccmal - Me-redmal - Me-ccmal - Me-ccmal) + (ccmal - ccmal) + (Me-ccmal - Me-ccmal) + (ohmal)
Non-colinear ordering:: vstA1 + vstA2 + vstA3 + vstA4 + vstA5

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

vstA1: mal - pk - mmal - mal - mmal

PKS_AT (538..846): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 83.3%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.7
inactive: 115.5
Methoxymalonyl-CoA: 68.1
Methylmalonyl-CoA: 43.5
Propionyl-CoA: 32.6
Isobutyryl-CoA: 30.5
Acetyl-CoA: 19.6
fatty_acid: 13.6
Ethylmalonyl-CoA: 12.7
2-Methylbutyryl-CoA: 12.0
Benzoyl-CoA: 10.9
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1697..2004): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 216.6
Methylmalonyl-CoA: 216.5
Methoxymalonyl-CoA: 176.0
2-Methylbutyryl-CoA: 163.0
trans-1,2-CPDA: 130.1
Propionyl-CoA: 116.0
CHC-CoA: 110.5
Malonyl-CoA: 99.9
Isobutyryl-CoA: 75.2
Benzoyl-CoA: 57.6
fatty_acid: 44.2
3-Methylbutyryl-CoA: 37.4
Acetyl-CoA: 34.3
inactive: 20.8

PKS_AT (3547..3849): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 83.3%; Malonyl-CoA: 75.0%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 163.8
Ethylmalonyl-CoA: 145.6
Methoxymalonyl-CoA: 135.5
Propionyl-CoA: 116.3
2-Methylbutyryl-CoA: 101.0
Malonyl-CoA: 86.3
CHC-CoA: 85.8
trans-1,2-CPDA: 75.6
Isobutyryl-CoA: 50.1
Benzoyl-CoA: 43.4
inactive: 33.7
Acetyl-CoA: 23.9
3-Methylbutyryl-CoA: 17.1
fatty_acid: 16.3

PKS_AT (5278..5575): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 157.0
inactive: 73.6
Methoxymalonyl-CoA: 68.5
Methylmalonyl-CoA: 52.7
Propionyl-CoA: 39.2
Ethylmalonyl-CoA: 24.7
Isobutyryl-CoA: 23.9
fatty_acid: 19.8
Acetyl-CoA: 15.6
CHC-CoA: 13.7
Benzoyl-CoA: 10.1
trans-1,2-CPDA: 8.3
2-Methylbutyryl-CoA: 4.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (7318..7624): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 83.3%; Malonyl-CoA: 75.0%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 167.3
Ethylmalonyl-CoA: 145.9
Methoxymalonyl-CoA: 138.3
Propionyl-CoA: 120.9
2-Methylbutyryl-CoA: 110.1
Malonyl-CoA: 87.9
CHC-CoA: 87.4
trans-1,2-CPDA: 78.4
Isobutyryl-CoA: 56.1
Benzoyl-CoA: 44.3
inactive: 33.4
3-Methylbutyryl-CoA: 21.3
Acetyl-CoA: 20.9
fatty_acid: 17.4

vstA2: mmal - mmal - mmal - mmal

PKS_AT (568..874): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 83.3%; Malonyl-CoA: 75.0%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 167.3
Ethylmalonyl-CoA: 145.9
Methoxymalonyl-CoA: 138.3
Propionyl-CoA: 120.9
2-Methylbutyryl-CoA: 110.1
Malonyl-CoA: 87.9
CHC-CoA: 87.4
trans-1,2-CPDA: 78.4
Isobutyryl-CoA: 56.1
Benzoyl-CoA: 44.3
inactive: 33.4
3-Methylbutyryl-CoA: 21.3
Acetyl-CoA: 20.9
fatty_acid: 17.4

PKS_AT (2382..2688): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 83.3%; Malonyl-CoA: 75.0%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 164.4
Ethylmalonyl-CoA: 146.7
Methoxymalonyl-CoA: 134.8
Propionyl-CoA: 119.0
2-Methylbutyryl-CoA: 106.3
Malonyl-CoA: 87.5
CHC-CoA: 87.0
trans-1,2-CPDA: 79.0
Isobutyryl-CoA: 54.0
Benzoyl-CoA: 44.3
inactive: 33.5
3-Methylbutyryl-CoA: 20.4
Acetyl-CoA: 20.0
fatty_acid: 17.4

PKS_AT (4484..4783): mmal

ATSignature: Methylmalonyl-CoA, Ethylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 79.2%; Ethylmalonyl-CoA: 79.2%; Malonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 148.6
Ethylmalonyl-CoA: 138.0
Methoxymalonyl-CoA: 128.6
2-Methylbutyryl-CoA: 115.8
Propionyl-CoA: 90.6
trans-1,2-CPDA: 86.0
CHC-CoA: 81.4
Malonyl-CoA: 60.6
Isobutyryl-CoA: 52.5
Benzoyl-CoA: 41.3
Acetyl-CoA: 35.8
inactive: 13.9
3-Methylbutyryl-CoA: 5.0
fatty_acid: 0.0

PKS_AT (6261..6567): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 83.3%; Malonyl-CoA: 75.0%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 165.4
Ethylmalonyl-CoA: 146.3
Methoxymalonyl-CoA: 135.6
Propionyl-CoA: 118.0
2-Methylbutyryl-CoA: 105.9
Malonyl-CoA: 86.0
CHC-CoA: 83.8
trans-1,2-CPDA: 79.5
Isobutyryl-CoA: 54.2
Benzoyl-CoA: 44.4
inactive: 32.7
3-Methylbutyryl-CoA: 20.4
Acetyl-CoA: 19.9
fatty_acid: 16.7

vstA3: mal - mal

PKS_AT (627..924): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 157.0
inactive: 73.6
Methoxymalonyl-CoA: 68.5
Methylmalonyl-CoA: 52.7
Propionyl-CoA: 39.2
Ethylmalonyl-CoA: 24.7
Isobutyryl-CoA: 23.9
fatty_acid: 19.8
Acetyl-CoA: 15.6
CHC-CoA: 13.7
Benzoyl-CoA: 10.1
trans-1,2-CPDA: 8.3
2-Methylbutyryl-CoA: 4.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (2347..2644): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 155.7
inactive: 72.3
Methoxymalonyl-CoA: 68.5
Methylmalonyl-CoA: 52.6
Propionyl-CoA: 37.5
Isobutyryl-CoA: 24.1
Ethylmalonyl-CoA: 23.1
fatty_acid: 19.6
Acetyl-CoA: 15.6
CHC-CoA: 13.6
Benzoyl-CoA: 10.6
trans-1,2-CPDA: 6.9
2-Methylbutyryl-CoA: 5.5
3-Methylbutyryl-CoA: 0.0

vstA4: mmal - mmal

PKS_AT (580..886): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 83.3%; Malonyl-CoA: 75.0%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 167.6
Ethylmalonyl-CoA: 150.4
Methoxymalonyl-CoA: 138.6
Propionyl-CoA: 120.2
2-Methylbutyryl-CoA: 108.2
Malonyl-CoA: 91.6
CHC-CoA: 88.3
trans-1,2-CPDA: 78.8
Isobutyryl-CoA: 54.9
Benzoyl-CoA: 43.8
inactive: 32.6
3-Methylbutyryl-CoA: 21.3
Acetyl-CoA: 20.8
fatty_acid: 16.2

PKS_AT (2331..2630): mmal

ATSignature: Methylmalonyl-CoA, Ethylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 79.2%; Ethylmalonyl-CoA: 79.2%; Malonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 148.6
Ethylmalonyl-CoA: 138.0
Methoxymalonyl-CoA: 128.6
2-Methylbutyryl-CoA: 115.8
Propionyl-CoA: 90.6
trans-1,2-CPDA: 86.0
CHC-CoA: 81.4
Malonyl-CoA: 60.6
Isobutyryl-CoA: 52.5
Benzoyl-CoA: 41.3
Acetyl-CoA: 35.8
inactive: 13.9
3-Methylbutyryl-CoA: 5.0
fatty_acid: 0.0

vstA5: mal

PKS_AT (576..866): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 228.6
inactive: 115.1
Methoxymalonyl-CoA: 76.2
Methylmalonyl-CoA: 57.7
Isobutyryl-CoA: 40.4
Propionyl-CoA: 32.5
Ethylmalonyl-CoA: 31.5
Acetyl-CoA: 24.8
2-Methylbutyryl-CoA: 18.4
fatty_acid: 17.8
Benzoyl-CoA: 17.2
CHC-CoA: 10.9
trans-1,2-CPDA: 9.0
3-Methylbutyryl-CoA: 7.4

Link to PARAS substrate predictor