Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001212.1:
Cluster 1NRP / Polyketide155222

BGC0001212, nannocystin biosynthetic gene cluster from Nannocystis sp. MB1016. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: nannocystin a
SMILES string: Copy to clipboard
Molecular formula: C42H55Cl2N3O9
Exact molecular mass: 816.8 Da (None)
Molecular activity: Antifungal, Cytotoxic
Molecular target: eukaryotic translation elongation factor 1a (EF-1a)

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (cyclic)
Thioesterase type:
Type I
Release / cyclization type:
Macrolactonization

Polyketide subclass:
Macrolide (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Benzoyl-CoA
Thioesterase type:
None
Release / cyclization type:
Macrolactonization

Gene cluster description

nannocystin (BGC0001212). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank KT067736. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Esther Schmitt (Novartis Institutes for BioMedical Research)

Literature references

1. Krastel P et al. (2015) Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti-Cancer Properties. Angew Chem Int Ed Engl 54(35):10149-54. doi: 10.1002/anie.201505069.