BGC0001214: marformycin A biosynthetic gene cluster from Streptomyces drozdowiczii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 47,529 nt. (total: 47,529 nt).
This entry is originally from NCBI GenBank KP715145.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001214
Short description marformycin A biosynthetic gene cluster from Streptomyces drozdowiczii
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KP715145.1
via
Compounds
  • marformycin A
  • marformycin B
  • marformycin C
  • marformycin D
  • marformycin E
  • marformycin F
Species Streptomyces drozdowiczii [taxonomy]
References
Chemical products information
marformycin A Evidence:
Copy SMILES
C43H68N8O10
Chemical database entries
NPAtlas
marformycin B Evidence:
Copy SMILES
C44H70N8O10
Chemical database entries
NPAtlas
marformycin C Evidence:
Copy SMILES
C43H68N8O11
Chemical database entries
NPAtlas
marformycin D Evidence:
Copy SMILES
C44H70N8O11
Chemical database entries
NPAtlas
marformycin E Evidence:
Copy SMILES
C42H66N8O11
Chemical database entries
NPAtlas
marformycin F Evidence:
Copy SMILES
C42H66N8O10
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AJV88371.1
 1 - 1512 (+) hypothetical protein
    copy AA seq
    copy Nt seq
    • AJV88372.1
    		 1634 - 2599 (+) nucleotide-binding protein
      copy AA seq
      copy Nt seq
      • AJV88373.1
      		 3153 - 3746 (-) MfnA
        copy AA seq
        copy Nt seq
        • AJV88374.1
        		 3875 - 4597 (-) MfnB
          copy AA seq
          copy Nt seq
          • AJV88375.1
          		 5165 - 16174 (+) MfnC
            copy AA seq
            copy Nt seq
            • AJV88376.1
            		 16156 - 20772 (+) MfnD
              copy AA seq
              copy Nt seq
              • AJV88377.1
              		 20790 - 31691 (+) MfnE
                copy AA seq
                copy Nt seq
                • AJV88378.1
                		 31743 - 31970 (+) MfnF
                  copy AA seq
                  copy Nt seq
                  • AJV88379.1
                  		 31967 - 33094 (+) MfnG
                    copy AA seq
                    copy Nt seq
                    • AJV88380.1
                    		 33094 - 33444 (+) MfnH
                      copy AA seq
                      copy Nt seq
                      • AJV88381.1
                      		 33479 - 34774 (+) MfnI
                        copy AA seq
                        copy Nt seq
                        • AJV88382.1
                        		 34780 - 35436 (+) MfnJ
                          copy AA seq
                          copy Nt seq
                          • AJV88383.1
                          		 35426 - 37030 (+) MfnK
                            copy AA seq
                            copy Nt seq
                            • AJV88384.1
                            		 37050 - 37322 (+) MfnL
                              copy AA seq
                              copy Nt seq
                              • AJV88385.1
                              		 37400 - 38125 (+) MfnM
                                copy AA seq
                                copy Nt seq
                                • AJV88386.1
                                		 38122 - 39396 (+) MfnN
                                  copy AA seq
                                  copy Nt seq
                                  • AJV88387.1
                                  		 39866 - 40987 (+) MfnO
                                    copy AA seq
                                    copy Nt seq
                                    • AJV88388.1
                                    		 41632 - 42024 (+) MfnP
                                      copy AA seq
                                      copy Nt seq
                                      • AJV88389.1
                                      		 42158 - 42538 (-) MfnQ
                                        copy AA seq
                                        copy Nt seq
                                        • AJV88390.1
                                        		 42512 - 44158 (+) MfnR
                                          copy AA seq
                                          copy Nt seq
                                          • AJV88391.1
                                          		 44653 - 45135 (-) transposase
                                            copy AA seq
                                            copy Nt seq
                                            • AJV88392.1
                                            		 46379 - 46894 (+) transposase
                                              copy AA seq
                                              copy Nt seq
                                              • AJV88393.1
                                              		 47096 - 47266 (+) ATP/GTP-binding protein
                                                copy AA seq
                                                copy Nt seq
                                                • AJV88394.1
                                                		 47395 - 47529 (+) hypothetical protein
                                                  copy AA seq
                                                  copy Nt seq
                                                  Biosynthesis information

                                                  Biosynthetic modules

                                                  Name
                                                  Unk01
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  AJV88375.1
                                                  Substrates
                                                  valine, allo-isoleucine (evidence: Structure-based inference, Sequence-based prediction)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk02
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  AJV88375.1
                                                  Substrates
                                                  threonine (evidence: Structure-based inference, Sequence-based prediction)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk03
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  AJV88375.1
                                                  Substrates
                                                  tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk04
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  AJV88376.1
                                                  Substrates
                                                  valine, allo-isoleucine (evidence: Structure-based inference, Sequence-based prediction, Knock-out studies)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk05
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  AJV88377.1
                                                  Substrates
                                                  leucine (evidence: Structure-based inference, Sequence-based prediction)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk06
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  AJV88377.1
                                                  Substrates
                                                  valine (evidence: Structure-based inference, Sequence-based prediction)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk07
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  AJV88383.1
                                                  Substrates
                                                  piperazic acid (evidence: Structure-based inference, Sequence-based prediction)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Annotation changelog

                                                  Entry version: 4

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-10-07
                                                  Update chemical activity to schema version 2.11
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 3

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-09-15
                                                  Updated bioactivity data
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-09-15
                                                  Added NRP substrate specificities
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 2

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2019-10-16
                                                  Migrated from v1.4
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2019-10-16
                                                  Updated compound(s) information (NPAtlas curation)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 1

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2015-08-17
                                                  Submitted
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  Detailed domain annotation
                                                  Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                  A domain glossary is available here, and an explanation of the visualisation is available here.
                                                  Selected features only
                                                  Show module domains
                                                  Similar known gene clusters from MIBiG 4.0
                                                  Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                  Click on reference genes to show details of similarities to genes within the current region.
                                                  Click on an accession to open that entry in the MiBIG database.