BGC0001216: splenocin C biosynthetic gene cluster from Streptomyces sp. CNQ431
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Location: 6,356 - 31,635 nt. (total: 25,280 nt).
This entry is originally from NCBI GenBank KP719128.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General
Compounds
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Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001216
Short description splenocin C biosynthetic gene cluster from Streptomyces sp. CNQ431
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
KP719128.1
6356 - 31635
via
Compounds
  • splenocin C
Species Streptomyces sp. CNQ431 [taxonomy]
References
Chemical products information
splenocin C Evidence:
Copy SMILES
C29H34N2O9
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AKA54624.1
  • spnA
 6356 - 6877 (-) putative RNA polymerase sigma factor
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    • AKA54625.1
    • spnB
    		 6935 - 8236 (-) acyltransferase
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      • AKA54626.1
      • spnC
      		 8880 - 17573 (+) NRPS
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        • AKA54627.1
        • spnD
        		 17566 - 21387 (+) PKS
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          • AKA54628.1
          • spnE
          		 21443 - 22663 (+) crotonyl-CoA reductive carboxylase
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            • AKA54629.1
            		 22767 - 23108 (-) transposase
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              • AKA54630.1
              • spnF
              		 23278 - 24564 (-) AMP dependent CoA-ligase
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                • AKA54631.1
                • spnG
                		 24756 - 25004 (-) ACP
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                  • AKA54632.1
                  • spnH
                  		 25305 - 26360 (+) phenylacetate-CoA oxygenase PaaA
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                    • AKA54633.1
                    • spnI
                    		 26465 - 26659 (+) phenylacetate-CoA oxygenase PaaB
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                      • AKA54634.1
                      • spnJ
                      		 26652 - 27440 (+) phenylacetate-CoA oxygenase PaaC
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                        • AKA54635.1
                        • spnK
                        		 27533 - 27955 (+) phenylacetate-CoA oxygenase PaaD
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                          • AKA54636.1
                          • spnL
                          		 27967 - 29070 (+) phenylacetate-CoA oxygenase PaaE
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                            • AKA54637.1
                            • spnM
                            		 29105 - 29881 (+) 3-oxoacyl-ACP reductase
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                              • AKA54638.1
                              • spnN
                              		 29928 - 30776 (+) tryptophan 2,3-dioxygenase
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                                • AKA54639.1
                                • spnO
                                		 30958 - 31635 (+) esterase
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                                  Biosynthesis information
                                  Annotation changelog

                                  Entry version: 4

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-10-07
                                  Update chemical activity to schema version 2.11
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 3

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Add compound details
                                  • (ID: SJG3CBEHSM6A3I74YXLH6GLA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Updated bioactivity data
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2019-10-16
                                  Migrated from v1.4
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2015-08-17
                                  Submitted
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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