BGC0001266 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001266 (Cladonia grayi)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	29,999	High	grayanic acid	PKS

BGC0001266 - Region 1 - T1PKS

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Location: 1 - 29,999 nt. (total: 29,999 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 30,000
Label		BGC0001266

Tailoring functions

Oxidoreductases: oxygenase

P450: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Transferases: methyltransferase

ADM79461.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Ligases: synthase

PKS16: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001266.3	1.00	PKS	grayanic acid	Cladonia grayi
BGC0001258.3	0.78	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.3	0.78	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001257.3	0.77	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002175.3	0.77	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002154.2	0.77	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001284.4	0.77	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001266.3	1.00	PKS	grayanic acid	Cladonia grayi
BGC0001258.3	0.78	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.3	0.78	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001257.3	0.77	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002175.3	0.77	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002154.2	0.77	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001284.4	0.77	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 29999:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

PKS16: mal

PKS_AT (892..1195): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; Methylmalonyl-CoA: 54.2%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 94.9
Methoxymalonyl-CoA: 61.0
Methylmalonyl-CoA: 59.2
inactive: 57.2
Propionyl-CoA: 29.5
Ethylmalonyl-CoA: 22.2
2-Methylbutyryl-CoA: 22.1
Benzoyl-CoA: 19.5
Acetyl-CoA: 15.6
CHC-CoA: 15.3
Isobutyryl-CoA: 13.3
3-Methylbutyryl-CoA: 13.3
fatty_acid: 11.9
trans-1,2-CPDA: 10.5

Link to PARAS substrate predictor