BGC0001288 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001288 (Micromonospora sp. GMKU326)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS,PKS-like	1	149,333	High	maklamicin	PKS

BGC0001288 - Region 1 - PKS-like,T1PKS

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Location: 1 - 149,333 nt. (total: 149,333 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
PKS-like: (t2pks2 or ksIII)

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core biosynthetic genes

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transport-related genes

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 149,334
Label		BGC0001288

Tailoring functions

Oxidoreductases: oxygenase

BAQ25476.1: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

BAQ25478.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

makC1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

makC2: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

makC3: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: PPTase acylase glycosyltransferase halogenase transferase

BAQ25480.1: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

BAQ25496.1: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

BAQ25509.1: flavin-dependent pyrrole halogenase

halogenases: flavin-dependent pyrrole halogenase
smcogs: SMCOG1119: halogenase

makA2: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

makA6: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1060: 4'-phosphopantetheinyl transferase

makD2: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Hydrolases: esterase phosphatase

makA5: thioesterase

smcogs: SMCOG1004: thioesterase

makB2: FkbH like protein

smcogs: SMCOG1256: FkbH like protein

Lyases: cyclase dehydratase

BAQ25475.1: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

BAQ25479.1: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

BAQ25497.1: Diels-Alderase cyclase

extras: DA_cyclase: Diels-Alderase cyclase

Ligases: ligase synthase

BAQ25481.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

BAQ25482.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

BAQ25490.1: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

BAQ25506.1: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

BAQ25507.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

makA1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

makA3: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

makA4: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

makB1: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

makD1: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001288.5	1.81	PKS	maklamicin	Micromonospora sp. GMKU326
BGC0001276.3	1.61	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	1.41	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	1.39	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002154.2	1.32	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002191.2	1.29	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001160.5	1.25	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	1.24	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002192.3	1.21	PKS	FR901512	fungal sp. No.14919
BGC0000037.4	1.17	PKS	cichorine	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001288.5	1.00	PKS	maklamicin	Micromonospora sp. GMKU326
BGC0001276.3	0.78	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.77	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.77	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002608.2	0.76	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002341.2	0.75	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 149333:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal - ccmal - Me-ccmal - Me-ccmal - ccmal) + (Me-ccmal - ccmal - ccmal - Me-ccmal) + (Me-redmal - Me-ccmal) + (mal) + (Me-ccmal - ccmal - ccmal - Me-redmal) + (redmal - Me-ccmal) + (pk)
Non-colinear ordering:: makA1 + BAQ25481.1 + BAQ25482.1 + makA4 + makA2 + makA3 + BAQ25507.1

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 64146:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal - ccmal - ccmal - Me-ccmal) + (Me-redmal - Me-ccmal) + (mal)
Non-colinear ordering:: BAQ25481.1 + BAQ25482.1 + makA4

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 31468 - 72506:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal - Me-ccmal) + (mal) + (pk)
Non-colinear ordering:: BAQ25482.1 + makA4 + BAQ25507.1

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 48259 - 89300:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal - ccmal - Me-ccmal - Me-ccmal - ccmal) + (pk)
Non-colinear ordering:: makA1 + BAQ25507.1

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 49341 - 149333:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal - ccmal - Me-ccmal - Me-ccmal - ccmal) + (Me-ccmal - ccmal - ccmal - Me-redmal) + (redmal - Me-ccmal) + (pk)
Non-colinear ordering:: makA1 + makA2 + makA3 + BAQ25507.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

BAQ25481.1: mmal - mal - mal - mmal

PKS_AT (658..953): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 79.2%; Ethylmalonyl-CoA: 70.8%; Methoxymalonyl-CoA: 70.8%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 166.8
Methoxymalonyl-CoA: 136.4
Ethylmalonyl-CoA: 127.5
2-Methylbutyryl-CoA: 108.4
trans-1,2-CPDA: 105.0
CHC-CoA: 99.2
Propionyl-CoA: 96.3
Malonyl-CoA: 88.6
Isobutyryl-CoA: 77.6
Benzoyl-CoA: 55.2
fatty_acid: 53.4
3-Methylbutyryl-CoA: 38.7
Acetyl-CoA: 32.8
inactive: 16.6

PKS_AT (2439..2729): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 171.5
inactive: 91.3
Methoxymalonyl-CoA: 55.1
Methylmalonyl-CoA: 45.0
Propionyl-CoA: 28.4
Ethylmalonyl-CoA: 22.7
fatty_acid: 20.3
Isobutyryl-CoA: 19.3
Acetyl-CoA: 18.0
Benzoyl-CoA: 11.9
CHC-CoA: 9.4
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (4159..4446): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 175.6
inactive: 83.9
Methoxymalonyl-CoA: 53.6
Methylmalonyl-CoA: 40.9
Propionyl-CoA: 28.9
Ethylmalonyl-CoA: 22.2
fatty_acid: 18.7
Isobutyryl-CoA: 17.9
Acetyl-CoA: 17.6
Benzoyl-CoA: 9.4
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (5883..6226): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 195.5
Ethylmalonyl-CoA: 187.7
Methoxymalonyl-CoA: 169.0
2-Methylbutyryl-CoA: 141.2
Propionyl-CoA: 125.2
trans-1,2-CPDA: 113.5
CHC-CoA: 105.5
Malonyl-CoA: 98.3
Isobutyryl-CoA: 64.9
Benzoyl-CoA: 49.7
inactive: 30.9
fatty_acid: 30.8
3-Methylbutyryl-CoA: 29.4
Acetyl-CoA: 23.2

BAQ25482.1: mmal - mmal

PKS_AT (582..920): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 189.7
Ethylmalonyl-CoA: 174.6
Methoxymalonyl-CoA: 165.0
2-Methylbutyryl-CoA: 137.5
Propionyl-CoA: 121.2
trans-1,2-CPDA: 118.4
CHC-CoA: 109.7
Malonyl-CoA: 97.0
Isobutyryl-CoA: 58.2
Benzoyl-CoA: 50.1
inactive: 32.6
fatty_acid: 31.6
3-Methylbutyryl-CoA: 23.6
Acetyl-CoA: 21.3

PKS_AT (2673..3018): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 83.3%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.3
Ethylmalonyl-CoA: 183.5
Methoxymalonyl-CoA: 166.8
2-Methylbutyryl-CoA: 135.4
Propionyl-CoA: 120.9
trans-1,2-CPDA: 117.7
CHC-CoA: 113.8
Malonyl-CoA: 99.9
Isobutyryl-CoA: 61.7
Benzoyl-CoA: 51.5
inactive: 33.4
fatty_acid: 32.1
Acetyl-CoA: 25.4
3-Methylbutyryl-CoA: 24.7

makA4: mal

PKS_AT (572..861): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 183.2
inactive: 83.2
Methoxymalonyl-CoA: 70.3
Methylmalonyl-CoA: 48.0
Propionyl-CoA: 34.1
Acetyl-CoA: 21.0
Isobutyryl-CoA: 17.9
fatty_acid: 17.7
Ethylmalonyl-CoA: 15.0
Benzoyl-CoA: 14.3
2-Methylbutyryl-CoA: 11.7
CHC-CoA: 10.2
trans-1,2-CPDA: 8.3
3-Methylbutyryl-CoA: 0.0

BAQ25507.1: pk

PKS_AT (543..833): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; Methylmalonyl-CoA: 70.8%; Propionyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 126.1
Methoxymalonyl-CoA: 100.3
Ethylmalonyl-CoA: 98.3
Malonyl-CoA: 73.7
trans-1,2-CPDA: 64.1
Isobutyryl-CoA: 63.8
Propionyl-CoA: 62.7
2-Methylbutyryl-CoA: 51.2
Acetyl-CoA: 42.7
Benzoyl-CoA: 38.3
fatty_acid: 37.7
3-Methylbutyryl-CoA: 34.8
CHC-CoA: 26.4
inactive: 11.7

makA1: mal - mmal - mal - mmal - mmal - mal

PKS_AT (575..871): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.4
inactive: 112.5
Methoxymalonyl-CoA: 64.0
Methylmalonyl-CoA: 55.0
Propionyl-CoA: 33.0
Isobutyryl-CoA: 27.4
Acetyl-CoA: 25.4
Benzoyl-CoA: 19.5
trans-1,2-CPDA: 12.3
CHC-CoA: 11.8
fatty_acid: 8.0
2-Methylbutyryl-CoA: 7.4
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -3.5

PKS_AT (1613..1960): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.1
Ethylmalonyl-CoA: 177.8
Methoxymalonyl-CoA: 165.2
2-Methylbutyryl-CoA: 133.4
Propionyl-CoA: 117.4
CHC-CoA: 110.4
trans-1,2-CPDA: 108.8
Malonyl-CoA: 96.0
Isobutyryl-CoA: 60.4
Benzoyl-CoA: 51.8
inactive: 35.1
fatty_acid: 33.6
3-Methylbutyryl-CoA: 24.8
Acetyl-CoA: 23.0

PKS_AT (3387..3677): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.4
inactive: 85.4
Methoxymalonyl-CoA: 59.3
Methylmalonyl-CoA: 48.8
Propionyl-CoA: 26.6
Isobutyryl-CoA: 21.4
Acetyl-CoA: 14.8
fatty_acid: 10.9
Ethylmalonyl-CoA: 8.6
Benzoyl-CoA: 8.0
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (5170..5513): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 189.2
Ethylmalonyl-CoA: 174.3
Methoxymalonyl-CoA: 160.0
2-Methylbutyryl-CoA: 133.2
Propionyl-CoA: 119.9
CHC-CoA: 111.6
trans-1,2-CPDA: 109.7
Malonyl-CoA: 96.8
Isobutyryl-CoA: 56.4
Benzoyl-CoA: 47.6
inactive: 35.6
fatty_acid: 34.9
Acetyl-CoA: 21.4
3-Methylbutyryl-CoA: 18.8

PKS_AT (6930..7273): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 192.2
Ethylmalonyl-CoA: 181.3
Methoxymalonyl-CoA: 160.7
2-Methylbutyryl-CoA: 134.8
Propionyl-CoA: 121.5
trans-1,2-CPDA: 110.6
CHC-CoA: 110.2
Malonyl-CoA: 100.2
Isobutyryl-CoA: 59.5
Benzoyl-CoA: 47.9
inactive: 31.4
fatty_acid: 28.7
Acetyl-CoA: 24.1
3-Methylbutyryl-CoA: 22.9

PKS_AT (8702..8992): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 176.8
inactive: 90.2
Methoxymalonyl-CoA: 56.5
Methylmalonyl-CoA: 42.6
Propionyl-CoA: 27.2
Isobutyryl-CoA: 21.5
Ethylmalonyl-CoA: 18.1
fatty_acid: 17.6
Acetyl-CoA: 14.8
Benzoyl-CoA: 9.0
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

makA2: mmal - mal - mal - mmal

PKS_AT (635..930): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 79.2%; Ethylmalonyl-CoA: 70.8%; Methoxymalonyl-CoA: 70.8%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 165.5
Methoxymalonyl-CoA: 135.6
Ethylmalonyl-CoA: 128.1
2-Methylbutyryl-CoA: 109.5
trans-1,2-CPDA: 106.0
CHC-CoA: 100.5
Propionyl-CoA: 97.0
Malonyl-CoA: 84.8
Isobutyryl-CoA: 78.6
Benzoyl-CoA: 55.4
fatty_acid: 53.4
3-Methylbutyryl-CoA: 38.9
Acetyl-CoA: 32.8
inactive: 16.5

PKS_AT (2355..2638): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 171.3
inactive: 86.3
Methoxymalonyl-CoA: 56.9
Methylmalonyl-CoA: 41.3
Propionyl-CoA: 25.1
Ethylmalonyl-CoA: 18.6
Acetyl-CoA: 18.6
Isobutyryl-CoA: 14.1
Benzoyl-CoA: 9.4
trans-1,2-CPDA: 0.0
fatty_acid: -0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (4087..4377): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 175.4
inactive: 88.6
Methoxymalonyl-CoA: 54.9
Methylmalonyl-CoA: 44.8
Propionyl-CoA: 20.9
fatty_acid: 18.9
Acetyl-CoA: 18.7
Isobutyryl-CoA: 17.0
Ethylmalonyl-CoA: 15.8
Benzoyl-CoA: 10.8
2-Methylbutyryl-CoA: 1.0
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (5841..6133): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 190.9
Ethylmalonyl-CoA: 178.2
Methoxymalonyl-CoA: 161.1
2-Methylbutyryl-CoA: 133.1
Propionyl-CoA: 121.3
CHC-CoA: 109.8
trans-1,2-CPDA: 108.2
Malonyl-CoA: 97.1
Isobutyryl-CoA: 57.8
Benzoyl-CoA: 51.4
inactive: 32.2
fatty_acid: 28.9
3-Methylbutyryl-CoA: 27.3
Acetyl-CoA: 25.6

makA3: mal - mmal

PKS_AT (586..876): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 169.8
inactive: 83.1
Methoxymalonyl-CoA: 54.3
Methylmalonyl-CoA: 44.3
Ethylmalonyl-CoA: 28.1
Propionyl-CoA: 26.8
Acetyl-CoA: 18.6
Isobutyryl-CoA: 15.4
Benzoyl-CoA: 13.7
2-Methylbutyryl-CoA: 9.5
trans-1,2-CPDA: 8.9
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
fatty_acid: -2.1

PKS_AT (2646..2940): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.4
Ethylmalonyl-CoA: 180.7
Methoxymalonyl-CoA: 163.8
2-Methylbutyryl-CoA: 136.6
Propionyl-CoA: 121.7
CHC-CoA: 107.7
trans-1,2-CPDA: 107.5
Malonyl-CoA: 98.8
Isobutyryl-CoA: 58.3
Benzoyl-CoA: 51.9
inactive: 32.3
3-Methylbutyryl-CoA: 28.1
fatty_acid: 27.5
Acetyl-CoA: 24.5

makD1: X

AMP-binding (10..370): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: --LFVGRITK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor