Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001327.1:
Cluster 1NRP / Polyketide138418

BGC0001327, rakicidin A / rakicidin B biosynthetic gene cluster from Micromonospora purpureochromogenes. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Rakicidin A
SMILES string: Copy to clipboard
Molecular formula: C32H54N3O7
Exact molecular mass: 607.4065 Da ([M+H]+)
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Cyclic depsipeptide (cyclic)
Thioesterase type:
Unknown
Release / cyclization type:
Macrolactonization

Nonribosomal peptide synthetases:
No gene ID (WP_030498974.1)
Module 2
A specificity: Serine
Evidence for specificity: Feeding study
C domain subtype: LCL
No gene ID (WP_052165466.1)
Module 4
A specificity: Glycine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Scaffold-modifying domain: Methylation
No gene ID (WP_030498977.1)
Module 5
A specificity: Beta-hydroxyasparagine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 6
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: LCL
Module is skipped
Evidence for skipping: Unknown
No gene ID (WP_030498980.1)
Module 7
A specificity: None
Evidence for specificity: Structure-based inference
C domain subtype: DCL
Module is skipped
Evidence for skipping: Unknown
Polyketide subclass:
Macrolide (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Other
Thioesterase type:
Unknown
Release / cyclization type:
Macrolactonization

Modular polyketide synthases:
No gene ID (WP_052165465.1)
Module 1
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

No gene ID (WP_030498975.1)
Module 3
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

Gene cluster description

rakicidin A / rakicidin B (BGC0001327). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank NZ_JOEU01000001, positions 164252-233421. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Thomas Torring (Aarhus University)

Literature references