BGC0001332: microtermolide A biosynthetic gene cluster from Streptomyces sp. MspMP-M5
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Location: 1 - 42,086 nt. (total: 42,086 nt).
This entry is originally from NCBI GenBank NZ_KB891904.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001332
Short description microtermolide A biosynthetic gene cluster from Streptomyces sp. MspMP-M5
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: NZ_KB891904.1
Compounds
  • microtermolide A
Species Streptomyces sp. MspMP-M5 [taxonomy]
References
Chemical products information
microtermolide A
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C23H37N3O6
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • B073_RS40860
  • WP_018540593.1
 1 - 8565 (-) type I polyketide synthase
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  • B073_RS0123835
  • WP_018540594.1
 8920 - 9303 (+) nuclear transport factor 2 family protein
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  • B073_RS0123840
  • WP_018540595.1
 9378 - 10556 (+) hypothetical protein
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  • B073_RS0123845
  • WP_051094164.1
 10635 - 12224 (-) aminotransferase class III-fold pyridoxal phosphate-dependent enzyme
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  • B073_RS42920
  • WP_018540597.1
 12272 - 14071 (-) AAA family ATPase
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  • B073_RS0123855
  • WP_234025150.1
 14125 - 14880 (-) alpha/beta fold hydrolase
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  • B073_RS0123860
  • WP_018540599.1
 15042 - 15872 (-) alpha/beta fold hydrolase
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  • B073_RS0123865
  • WP_026247673.1
 16131 - 16328 (-) (4Fe-4S)-binding protein
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  • B073_RS0123870
  • WP_018540601.1
  • fabG
 16361 - 17128 (-) 3-oxoacyl-ACP reductase FabG
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  • B073_RS0123875
  • WP_106731933.1
 17125 - 22878 (-) type I polyketide synthase
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  • B073_RS0123880
  • WP_018540603.1
 22884 - 26207 (-) non-ribosomal peptide synthetase
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  • B073_RS0123885
  • WP_018540604.1
 26204 - 29482 (-) type I polyketide synthase
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  • B073_RS0123890
  • WP_158690194.1
 29500 - 30057 (-) hypothetical protein
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  • B073_RS0123895
  • WP_018540606.1
  • ccrA
 30290 - 31633 (-) crotonyl-CoA carboxylase/reductase
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  • B073_RS0123900
  • WP_018540607.1
 32751 - 42086 (+) non-ribosomal peptide synthetase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
B073_RS0123880
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
B073_RS0123900
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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