BGC0001337: lazarimide A biosynthetic gene cluster from uncultured bacterium
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Location: 3,107 - 25,639 nt. (total: 22,533 nt).
This entry is originally from NCBI GenBank KR052816.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001337
Short description lazarimide A biosynthetic gene cluster from uncultured bacterium
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
KR052816.1
3107 - 25639
via Heterologous expression, Gene expression correlated with compound production
Compounds
  • lazarimide A
  • lazarimide B
  • lazarimide C
Species uncultured bacterium [taxonomy]
References
Chemical products information
lazarimide A Evidence: NMR, Mass spectrometry
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C22H15Cl2N3O6
lazarimide B Evidence:
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C22H15Cl2N3O5
lazarimide C Evidence:
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C20H11Cl2N3O4
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AKQ20686.1
  • lzrX1a
 3107 - 3502 (-) monooxygenase
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    • AKQ20687.1
    • lzrX1b
    		 3436 - 4686 (-) monooxygenase
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      • AKQ20688.1
      • lzrM1
      		 4824 - 5516 (+) N-methyltransferase
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        • AKQ20689.1
        • lzrP
        		 5513 - 6697 (-) RebP-like cytochrome p450
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          • AKQ20690.1
          • lzrC
          		 6694 - 8361 (-) RebC-like monooxygenase
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            • AKQ20691.1
            • lzrY1
            		 8539 - 9303 (+) putative alpha/beta hydrolase
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              • AKQ20692.1
              • lzrY2
              		 9282 - 9509 (+) putative alpha/beta hydrolase
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                • AKQ20693.1
                • lzrF
                		 9575 - 10054 (-) putative flavin reductase
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                  • AKQ20694.1
                  • lzrT1
                  		 10051 - 10545 (-) putative cation/H+ antiporter
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                    • AKQ20695.1
                    • lzrT2
                    		 10503 - 11270 (-) putative cation/H+ antiporter
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                      • AKQ20696.1
                      • lzrH1
                      		 11283 - 12821 (-) tryptophan-5 halogenase
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                        • AKQ20697.1
                        • lzrM3
                        		 12858 - 13859 (-) O-methyltransferase
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                          • AKQ20698.1
                          • lzrX2
                          		 13856 - 15109 (-) monooxygenase
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                            • AKQ20699.1
                            • lzrH2
                            		 15114 - 16706 (-) tryptophan-6 halogenase
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                              • AKQ20700.1
                              • lzrO
                              		 16907 - 18343 (+) RebO-like L-amino acid oxidase
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                                • AKQ20701.1
                                • lzrD
                                		 18340 - 21273 (+) RebD-like chromopyrrolic acid synthase
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                                  • AKQ20702.1
                                  • lzrG
                                  		 21266 - 22363 (-) cytochrome p450
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                                    • AKQ20703.1
                                    • lzrR
                                    		 22796 - 25639 (-) LuxR-type transcriptional regulator
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                                      Biosynthesis information
                                      Annotation changelog

                                      Entry version: 4

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-10-07
                                      Update chemical activity to schema version 2.11
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 3

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-09-15
                                      Updated bioactivity data
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2019-10-16
                                      Migrated from v1.4
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2016-09-03
                                      Submitted
                                      • (ID: TFC7LOLNUCTKZCZQ4X3ELKJ7)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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