Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001337.1:
Cluster 1Alkaloid122533

BGC0001337, lazarimide A / lazarimide B / lazarimide C biosynthetic gene cluster from uncultured bacterium. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: lazarimide A
SMILES string: Copy to clipboard
Molecular formula: C22H16Cl2N3O6
Exact molecular mass: 486.026 Da ([M-H]-)
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
Alkaloid
Alkaloid subclass:
Indole/benzopyrrole

Gene cluster description

lazarimide A / lazarimide B / lazarimide C (BGC0001337). Gene Cluster 1. Biosynthetic class = Alkaloid. GenBank KR052816, positions 3107-25639. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression, Gene expression correlated with compound production
MIxS-compliance:Unknown
Contact for this cluster:Fang-Yuan Chang (MIT)

Literature references

1. Montiel D et al. (2015) Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters. Proc Natl Acad Sci U S A 112(29):8953-8. doi: